Malene Højbjerre

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The minimal model was proposed in the late 1970s by Bergman et al. (Am. J. Physiol. 1979; 236(6):E667) as a powerful model consisting of three differential equations describing the glucose and insulin kinetics of a single individual. Considering the glucose and insulin simultaneously, the minimal model is a highly ill-posed estimation problem, where the(More)
BACKGROUND AND OBJECTIVE Insulin degludec is a basal insulin with a slow and distinct absorption mechanism resulting in an ultra-long, flat, and stable pharmacokinetic profile in patients with diabetes mellitus. The aim of this study was to examine the effect of hepatic impairment on the single-dose pharmacokinetics of insulin degludec. METHODS(More)
SUMMARY The prehepatic insulin secretion rate of the pancreatic β-cells is not directly measurable, since part of the secreted insulin is absorbed by the liver prior to entering the blood stream. However, C-peptide is co-secreted equimolarly and is not absorbed by the liver, allowing for the estimation of the prehepatic insulin secretion rate. We consider a(More)
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