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BACKGROUND AND OBJECTIVE Insulin degludec is a basal insulin with a slow and distinct absorption mechanism resulting in an ultra-long, flat, and stable pharmacokinetic profile in patients with diabetes mellitus. The aim of this study was to examine the effect of hepatic impairment on the single-dose pharmacokinetics of insulin degludec. METHODS(More)
The HLA allogenotypes DR1/Br, DR3 and DR10 (entitled risk HLA markers) have been reported as being genetic markers for the predisposition to experience unexplained recurrent fetal losses. The aim of the study was to determine whether the putative risk HLA markers might also be markers for the risk of pregnancy loss in sisters and wives of brothers of women(More)
The minimal model was proposed in the late 1970s by Bergman et al. (Am. J. Physiol. 1979; 236(6):E667) as a powerful model consisting of three differential equations describing the glucose and insulin kinetics of a single individual. Considering the glucose and insulin simultaneously, the minimal model is a highly ill-posed estimation problem, where the(More)
OBJECTIVE Metatarsalgia is often treated by metatarsal osteotomy. Exact knowledge of the normal anatomy of the forefoot is essential for pre-operative planning. The objective of this study was to investigate the forefoot arch during maximal loading in a randomly selected population sample. METHODS Two hundred subjects randomly selected from a municipality(More)
SUMMARY The prehepatic insulin secretion rate of the pancreatic β-cells is not directly measurable, since part of the secreted insulin is absorbed by the liver prior to entering the blood stream. However, C-peptide is co-secreted equimolarly and is not absorbed by the liver, allowing for the estimation of the prehepatic insulin secretion rate. We consider a(More)
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