Malek Mansour

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BACKGROUND Genetic risk factors play an important role in the pathogenesis of Alzheimer's disease (AD). In this case-control study, we examined the C677T and A1298C polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene and their correlation with this pathology. OBJECTIVE To verify the association between MTHFR C677T and A1298C(More)
OBJECTIVE The present study evaluated the role of the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C gene polymorphisms and correlated these results with plasma homocysteine (Hcy) levels in Tunisian ischemic stroke (IS) patients. METHODS Overall, 84 patients with IS were included and compared with 100 healthy controls. The most common stroke(More)
BACKGROUND AND OBJECTIVE Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune-mediated disorder of the peripheral nervous system (PNS). The aim of this study was to investigate associations between HLA-DR/DQ alleles and CIDP in Tunisian patients. PATIENTS AND METHODS HLA DR/DQ genotyping was performed using polymerase chain(More)
OBJECTIVE This study was designed to evaluate an innovative program of high speed radiographic screening for pulmonary tuberculosis (TB) at a large urban correctional institution, Cook County Jail in Chicago. METHODS From March 1992 to February 1994, 126,608 inmates were screened on intake with a 100-mm mini-chest radiograph. RESULTS Sixty-seven cases(More)
BACKGROUND The ɛ4 allele of the apolipoprotein E (APOE) gene is a well-characterized genetic risk factor for Alzheimer disease (AD). The association between stroke and a higher risk for AD has also been reported. Our study sought to determine the relationship between the APOE gene and AD and the comorbid risk of stroke. METHODS The subjects of this study(More)
BACKGROUND Data from African countries regarding diagnosis, prognosis, management, and outcome of patients with cerebral venous thrombosis (CVT) are limited. The aim of the present study is to characterize clinical presentation, predisposing factors, neuroimaging findings, and outcomes of the disease in the Tunisian population. METHODS This is a(More)
Celiac disease (CD) is an autoimmune disorder that occurs in genetically predisposed individuals in response to ingestion of gluten. Classical forms revealed by the triad malabsorption, diarrhea and abdominal pain represent only 10–20 % of cases and clinical presentation is often polymorphic [1]. Thrombotic events may occur in CD, and thrombosis is usually(More)
A 58-year-old postmenopausal woman had a personal history of aortic mechanical valve replacement 2 years ago, for which she received oral anticoagulation therapy with AVK (acenocoumarol). A year later, she experienced recurrent sudden-onset severe headache, reaching peak intensity within 1 min, and spontaneously resolving within few minutes. On admission a(More)