Malcolm Sainsbury

Learn More
The aim of this study was to discover if the forced inspired inert gas sinewave technique could be used to measure pulmonary blood flow, using nitrous oxide as the indicator gas, following inotropic stimulation of the heart by dobutamine, in the presence of a constant alveolar ventilation. Cardiac output (range 1-4.5 L min(-1)) was measured in six dogs by(More)
A theoretical model (Hahn et al. J. Appl. Physiol. 75: 1863-1876, 1993) predicts that the amplitudes of the argon and nitrous oxide inspired, end-expired, and mixed expired sinusoids at forcing periods in the range of 2-3 min (frequency 0.3-0.5 min-1) can be used directly to measure airway dead space, lung alveolar volume, and pulmonary blood flow. We(More)
1. Introduction 1 2. Sources of alkanes 1 3. Preparation of alkanes 2 (a) Reduction of alkenes and alkynes 2 (b) From alkyl halides and alcohols 4 (c) From thio-and seleno-compounds 6 (d) From carbonyl and carboxylic derivatives 6 (e) Using organometallic coupling reagents 8 (f) Other methods 9 4. Physical properties of alkanes 9 (a) Thermochemical(More)
  • H. G. Shertzer, M. Wilson Tabor, I. T. D. Hogan, Stephen J. Brown, Malcolm Sainsbury
  • 1996
 Many dietary constituents, such as indole-3-carbinol, are chemoprotective in toxicity and carcinogenicity bioassays. Indole-3-carbinol and related congeners appear to protect partly via radical and electrophile scavenging. To develop better chemoprotective indoles with lower intrinsic toxicity, we performed molecular graphic and quantum-mechanical analyses(More)
Continuous-ventilation mathematical gas exchange models are widely used since their analytical equations are amenable to physiological interpretation. They describe qualitatively the respiratory system's response to changing physiological conditions, but do not calculate accurate values for respiratory parameters when experimental tidal ventilation expired(More)
Simulation of lung ventilation using a model lung can provide a means of evaluating lung function tests, mathematical models and computer algorithms. We describe a new water-displacement lung model, which can simulate lung volumes up to 3.8 l and tidal volumes up to 1 l. Gas mixing is ensured by using a ring of venturi devices. Model compliance and airways(More)
In a model lung, airways dead-space can be accurately measured using a forced inspired oscillating argon signal, which varies sinusoidally about a mean concentration of 6% v/v with an amplitude of +/- 4% v/v. With sinusoid forcing periods longer than 120 seconds, and at a breathing rate of 13.4 breaths minute-1, the mean airways dead-space can be measured(More)
  • 1