Malcolm R Gamble

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Some common laboratory species are now considered unsuitable for the study of the toxicity of inhalants because of the natural incidence of abnormal respiratory histology. Levels of ammonia commonly encountered in animal boxes and cages have been shown to cause histopathological changes in the tracheal epithelium of rats, and it is suggested that 'abnormal(More)
Most local barrier systems are designed primarily either to protect animals from airborne contamination (exclusion) or to ensure the safety of personnel (hazard containment). Few, other than isolators, are able to cope with the often conflicting demands to do both. The Positive Individually Ventilated system (PIV), which provides pressure adjustable,(More)
Preface Whenever animals are used in research, minimizing pain and distress and promoting good welfare should be as important an objective as achieving the experimental results. This is important for humanitarian reasons, for good science, for economic reasons and in order to satisfy the broad legal principles in international legislation. It is possible to(More)
Vaginal smear cyclicity was used as a physiological test to compare the response of rats to the new "silent" fire alarm developed by the Laboratory Animals Centre with a conventional fire bell. The fire bell had a highly significant effect on the vaginal smear cyclicity whereas the rats exposed to the "silent" fire alarm showed no significant changes from(More)
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