Malcolm Collins

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There is growing basic-science interest in the mechanisms underpinning the positive effects of exercise on brain function and cognitive-affective performance. There is also increasing clinical evidence that exercise may prevent and treat various neuropsychiatric disorders. At the same time, there is growing awareness that athletic performance is mediated in(More)
Obesity, a chronic low-grade inflammatory condition is associated with the development of many comorbidities including dyslipidemia. This review examines interactions between single nucleotide polymorphisms (SNP) in the inflammatory genes tumor necrosis alpha (TNFA) and interleukin-6 (IL-6) and dietary fatty acids, and their relationship with obesity and(More)
OBJECTIVE — The purpose of this study was to characterize differences in the acute insulin response to glucose (AIR g) relative to insulin sensitivity (S I) in black and white premenopausal normoglycemic South African women matched for body fatness. RESEARCH DESIGN AND METHODS — Cross-sectional analysis including 57 black and white South African women(More)
This study analyzed the effect of caffeine ingestion on performance during a repeated-measures, 100-km, laboratory cycling time trial that included bouts of 1- and 4-km high intensity epochs (HIE). Eight highly trained cyclists participated in 3 separate trials' placebo ingestion before exercise with a placebo carbohydrate solution and placebo tablets(More)
Despite numerous attempts to discover genetic variants associated with elite athletic performance, injury predisposition, and elite/world-class athletic status, there has been limited progress to date. Past reliance on candidate gene studies predominantly focusing on genotyping a limited number of single nucleotide polymorphisms or the insertion/deletion(More)
The general consensus among sport and exercise genetics researchers is that genetic tests have no role to play in talent identification or the individualised prescription of training to maximise performance. Despite the lack of evidence, recent years have witnessed the rise of an emerging market of direct-to-consumer marketing (DTC) tests that claim to be(More)
DESCRIPTION: The book includes data about genetic factors which are related to sports performance and those which make an athlete prone to injuries. Under the light shed by recent developments about genetic contribution to many complex diseases, this book is an attempt to use the same approach in exercise science and sports medicine area. PURPOSE: To review(More)
We aimed to quantify the ACE I/D and ACTN3 R577X (rs1815739) genetic variants in elite rugby athletes (rugby union and league) and compare genotype frequencies to controls and between playing positions. The rugby athlete cohort consisted of 507 Caucasian men, including 431 rugby union athletes that for some analyses were divided into backs and forwards and(More)
This study investigated interactions between dietary fat intake and IL-6 polymorphisms on obesity and serum lipids in black and white South African (SA) women. Normal-weight and obese, black and white women underwent measurements of body composition, serum lipids and dietary fat intake, and were genotyped for the IL-6 -174 G>C, IVS3 +281 G>T and IVS4 +869(More)
The aim of this study was to examine the interaction between aging and 10 years of racing in endurance runners. Race-time data from 194 runners who had completed 10 consecutive 56-km ultramarathons were obtained. The runners were either 20.5 +/- 0.7, 30.0 +/- 1.0, 39.9 +/- 0.9, or 49.4 +/- 1.0 years old at their first race. Each runner's race speed was(More)