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The advantage of helium plasma treatment in enhancing endothelial cell growth and adhesion on polyurethane film coated on glass substrate is demonstrated with experimental data. Human coronary artery endothelial cell (HCAE) growth and attachment was studied on (1) bare glass substrate, used as control, (2) coated glass, with and without helium plasma(More)
Metered dose inhalers (MDIs) and dry powder inhalers (DPIs) are popular drug delivery devices used in the treatment of respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). Integrated effects of electrostatic charges and aerodynamic sizes on the deposition of MDI and DPI particles in a replica cast of human(More)
During the pharmaceutical powder blending process, electrostatic charges generate and accumulate unavoidably due to particle-particle and particle-wall collision. The effect of electrostatic charging on pharmaceutical powder blending homogeneity was investigated on two binary blending systems: (1) lactose as an excipient with caffeine as an Active(More)
Measurement of deposition of sidestream cigarette smoke in the human respiratory tract is important for assessing the health effects of sidestream cigarette smoke. We measured the deposition fraction of sidestream cigarette smoke in 5 normal adult male volunteers using sidestream smoke at a concentration similar to that encountered indoors with smokers(More)
Aerosol particles generated by inhalers for respiratory drug delivery acquire electrostatic charge during the dispersion process. The electrostatic charge distribution of the particles can affect the efficiency of drug delivery by influencing both the transport and deposition of inhaled particles in the human lung. To analyze the electrostatic charge(More)
Physical properties of two metered-dose bronchodilator aerosols packaged as solutions and two aerosols packaged as finely ground powders were measured at low and high relative humidity. The aerodynamic size distribution and particle concentration were measured in real time using the single-particle aerodynamic relaxation time analyzer, which can measure the(More)
The aerodynamic size distributions of 9 commonly used bronchodilator aerosols were determined by using a new instrument, the single-particle, aerodynamic relaxation time analyzer, which can measure the aerodynamic size of single particles and droplets in real time independent of density, shape, and other physical characteristics. The following commercial(More)
Particle size and mass concentration are important determinants of site and quantity of respiratory tract deposition of aerosols. Particle concentrations and size distributions of smoke from marijuana cigarettes with different concentrations (as measured in the marijuana leaf) of delta 9-tetrahydrocannabinol (delta 9-THC) were measured using a single(More)
Corrosion of metal stents implanted inside an artery can have two adverse effects: (1) tissue reaction and possible toxic effects from the metal ions leaching out of the stent, and (2) loss of mechanical strength of the stent caused by corrosion. The corrosion resistance of Nitinol (Nickel-Titanium) stents and its modulation with different film thickness of(More)
The anisotropic thermal diffusivity of aligned carbon nanotube-polymer composites was determined using a photothermoelectric technique. The composites were obtained by infiltrating poly-dimethyl siloxane (PDMS) in aligned multiwall CNT arrays grown by chemical vapor deposition on silicon substrates. The thermal diffusivities are insensitive to temperature(More)