Makoto Toyota

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UNLABELLED With this symposium, we focused on the relapse of tuberculosis in Japan. Out of 19,893 tuberculosis patients registered in 2007 in Japan, 7.48% were classified as relapse cases. Relapse cases have the risk of acquired drug resistance. But we have few analyses of the proportion of relapse tuberculosis cases with standard short course regimens for(More)
A 15-year-old man, who was a classmate with the index case of a large outbreak of tuberculosis in a junior high school in Kochi city, showed strongly positive reaction to tuberculin skin test in March 1999. After taking a chest X-ray film, which showed no abnormal finding, chemoprophylaxis with isoniazid was started in April 1999. He was compliant with(More)
Tuberculosis in the elderly remains a health burden in Japan. Most of the elderly aged more than 70 years in Japan had become infected with Mycobacterium tuberculosis in their youth, and the elderly represent a population at a special high risk for developing tuberculosis owing to comorbidity and age-related immunosuppression. The characteristics of(More)
A 15-year-old girl, third-grade student of a junior high school (the index case) was found to have smear-positive, cavitary pulmonary tuberculosis. Contact investigation was conducted, including tuberculin skin test and chest X-ray examinations over 700 persons. Tuberculin skin test revealed an excess of strongly-positive reactors in the third-grade(More)
It has been proposed that "the risk index" obtained by multiplying the score of sputum-smear examination (Gaffky number) by the duration of symptomatic period in months is useful for the prediction of the infectiousness of a tuberculosis patient. To verify this theory, contacts examination of 498 index cases, who were newly registered by the Kochi Chuo(More)
BACKGROUND Few studies have examined the validity of administering tuberculosis control measures based on tuberculin skin test (TST) erythema measurement. The present study aimed to clarify the relationship between the erythema and the induration seen following TST and to evaluate the validity of diagnosing tuberculosis infection based on the erythema(More)
PURPOSE To evaluate the various transmission routes of tuberculosis in an outbreak among young adults in order to develop an effective method for contact investigations. METHOD We reviewed the records of 21 tuberculosis patients involved in an outbreak of tuberculosis; the records were collected by conventional epidemiological studies. Mycobacterium(More)