Makoto Taiji

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Now, we come to offer you the right catalogues of book to open. scientific simulations with special purpose computers the grape systems is one of the literary work in this world in suitable to be reading material. That's not only this book gives reference, but also it will show you the amazing benefits of reading a book. Developing your countless minds is(More)
PURPOSE The first-generation ALK tyrosine kinase inhibitor (TKI) crizotinib is a standard therapy for patients with ALK-rearranged non-small cell lung cancer (NSCLC). Several next-generation ALK-TKIs have entered the clinic and have shown promising activity in crizotinib-resistant patients. As patients still relapse even on these next-generation ALK-TKIs,(More)
The spontaneous dominant mouse mutant, Elbow knee synostosis (Eks), shows elbow and knee joint synosotsis, and premature fusion of cranial sutures. Here we identify a missense mutation in the Fgf9 gene that is responsible for the Eks mutation. Through investigation of the pathogenic mechanisms of joint and suture synostosis in Eks mice, we identify a key(More)
We are developing the 'Protein Explorer' system, a petaflops special-purpose computer system for molecular dynamics simulations. The Protein Explorer is a PC cluster equipped with special-purpose engines that calculate nonbonded interactions between atoms, which is the most time-consuming part of the simulations. A dedicated LSI 'MDGRAPE-3 chip' performs(More)
The rapid and accurate molecular dynamics simulation of biomolecules was made possible by a special purpose computer, MD-GRAPE Ž . GRAvity PipE for Molecular Dynamics , which computes arbitrary central force and potential. A program package for the molecular dynamics simulation of Ž biological macromolecules was developed PEACH Program for Energetic .(More)
In this paper, we describe the implementation of gravitational force calculation for N -body simulations in the context of Astrophysics. It will describe high performance implementations on general purpose processors, GPUs, and FPGAs, and compare them using a number of criteria including speed performance, power efficiency and cost of development. These(More)
As an entry for the 2009 Gordon Bell price/performance prize, we present the results of two different hierarchical <i>N</i>-body simulations on a cluster of 256 graphics processing units (GPUs). Unlike many previous <i>N</i>-body simulations on GPUs that scale as <i>O</i>(<i>N</i><sup>2</sup>), the present method calculates the <i>O</i>(<i>N</i> log(More)
A new approach for the study of social games and communications is proposed. Games are simulated between cognitive players who build the opponent’s internal model and decide their next strategy from predictions based on the model. In this paper, internal models are constructed by the recurrent neural network (RNN), and the iterated prisoner’s dilemma game(More)
The Rac-specific guanine nucleotide exchange factor (GEF) Asef is activated by binding to the tumor suppressor adenomatous polyposis coli mutant, which is found in sporadic and familial colorectal tumors. This activated Asef is involved in the migration of colorectal tumor cells. The GEFs for Rho family GTPases contain the Dbl homology (DH) domain and the(More)
We have achieved a sustained performance of 55 TFLOPS for molecular dynamics simulations of the amyloid fibril formation of peptides from the yeast Sup35 in an aqueous solution. For performing the calculations, we used the MDGRAPE-3 system---a special-purpose computer system for molecular dynamics simulations. Its nominal peak performance was 415 TFLOPS for(More)