Makoto Oyaizu

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The effects of nefiracetam (DM-9384) on the neuronal nicotinic acetylcholine (ACh) receptor-channel were studied by the whole-cell patch clamp technique using PC12 cells. Nefiracetam had a dual effect on ACh-induced currents: it augmented the currents induced by low concentrations (10-30 microM) of ACh and suppressed those induced by high concentrations(More)
We have studied the effects of MS-551 on the inward rectifier potassium channel (IK1) in isolated guinea-pig ventricular myocytes by use of whole-cell and single-channel recording techniques. MS-551 (5 microM) blocked the IK1 current. The percent blockade of the peak and steady-state IK1 current by MS-551 was constant at each test potential. In contrast 50(More)
The differences among the small spines of 6 species of puffers have been clarified by means of microscopic observation. Small spines of puffers arise from the basement, which is composed of spines protruding from the surface skin, with roots extending horizontally in all directions in the layer under the surface skin. Using the characteristic shapes of the(More)
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