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The existence of sexual dimorphism in synaptic pattern is demonstrated in the molecular layer of the medial nucleus of the rat amygdala by semiquantitative electron microscopic analysis on synaptic density. Sex difference in synaptic number was found in dendritic shaft synapses in the medial part of the molecular layer, whereas the difference occurred in(More)
The density of cells in the anteroventral periventricular nucleus (AVPv) of the preoptic area of female rats was greater than that of males on day 21 of gestation. It appears that this difference between the sexes is caused by the action of androgen since the density of cells in the AVPv of female fetuses fell to the density in males when the mother(More)
Neurocan is a nervous tissue-unique chondroitin sulfate proteoglycan (CSPG) whose expression and proteolytic cleavage are developmentally regulated. In the adult rat brain, neurocan is completely cleaved into some proteoglycan fragments including the C-terminal half known as neurocan-C and a N-terminal fragment with a 130 kDa core glycoprotein(More)
Effect of short-term exposure to nerve growth factor (NGF) on neuron survival of superior cervical ganglion (SCG) transplanted into the third ventricle in rats and that on neurite outgrowth of SCG neurons in a tissue culture system were examined. Because SCG taken from 3 week-old rats exhibited a high survival rate in transplantation and they were highly(More)
The neurons in the hypothalamic arcuate nucleus (ARC) of 20-day-old female mice were examined by electron microscopy. The administration of estradiol-17 beta during 20 days from the day of birth resulted in the increase of dense-core vesicles (DCVs) in some neuronal perikarya of the middle region of the ARC (middle ARC), while, in the posterior region of(More)
Immunoreactivity specific to keratan sulfate (KS), heparan sulfate (HS), and chondroitin sulfate (CS) in the nasal region of chick embryos on embryonic day (ED) 3.5-7, was investigated with six antibodies and three glycosidases. Immunoreactivity specific to HS, KS, and CS, and their localized distribution was seen in the olfactory epithelium, olfactory(More)
Nuclear volume of the medial and lateral nuclei of the amygdala was investigated in male and female rats. The volume of the medial nucleus in the adult male rat was significantly greater than that of the female rat. Treatment of female rats with estrogen for the first 30 days of postnatal life increased the nuclear size, and the volume became comparable to(More)
Estrogen markedly promotes the specific formation of dendritic shaft synapses in the medial amygdaloid nucleus (AMN) of the rat when given in early postnatal days. The high incidence of this type of synapse permanently persists until sacrifice at adult ages. The data provide evidence for the synaptic plasticity of the developing amygdala to estrogen and(More)
Kindling stimulation was given in the basolateral amygdala (BLA), the septal area or the corpus callosum in the right hemisphere of adult rats. The density of dendritic synapses was electron microscopically studied in the medial amygdaloid nucleus (MAN) ipsi- and contralateral to the stimulation side. The number of dendritic synapses was markedly decreased(More)