Makoto Miyamae

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Epidemiologic studies indicate that long-term alcohol consumption decreases the incidence of coronary disease and may improve outcome after myocardial infarction. Attenuation of ischemia-reperfusion injury after myocardial infarction improves survival. This study investigates the possibility that alcohol consumption can improve survival after myocardial(More)
In addition to decreasing the incidence of myocardial infarction, recent epidemiological data suggest that regular alcohol consumption improves survival after myocardial infarction. We recently found that chronic ethanol exposure induces long-term protection against cardiac ischemia-reperfusion injury, which improves myocardial recovery after infarction.(More)
Assessment of free cytosolic [Ca2+] ([Ca2+]c) using the acetoxymethyl ester (AM) form of indo-1 may be compromised by loading of indo-1 into noncytosolic compartments, primarily mitochondria. To determine the fraction of noncytosolic fluorescence in whole hearts loaded with indo-1 AM, Mn2+ was used to quench cytosolic fluorescence. Residual (i.e.,(More)
We investigated the follow-up status and prognosis of 109 patients with non-insulin-dependent diabetes mellitus aged from 10 to 19 years old (66 males and 43 females). Patients who had not attended hospital for at least 20 months up to the end of September 1990 were regarded as defaulters, and were surveyed by questionnaire. There were 62 defaulters (56.9%)(More)
Intracellular calcium overload has been implicated in postischemic reperfusion injury. In myocytes, mitochondrial free calcium concentration ([Ca2+]m), not cytosolic free calcium concentration ([Ca2+]c), overload is related to reoxygenation injury. We tested the hypothesis that [Ca2+]m, not [Ca2+]c, overload is an important mediator of reperfusion injury in(More)
We recently discovered that regular alcohol consumption reduces ischemia-reperfusion injury to the same degree as ischemic preconditioning in guinea pig hearts. Ischemic preconditioning, like this cardioprotective effect of alcohol, is mediated by adenosine signaling in guinea pigs. In rats, ischemic preconditioning may be mediated predominantly by(More)
To determine the impact of continuous ambulatory peritoneal dialysis (CAPD) on cardiovascular risk factors in diabetic patients, we evaluated serum lipid profiles and plasma levels of coagulation and fibrinolysis parameters in 23 diabetic patients on long-term CAPD (aged 55 +/- 14 years, mean +/- SD), and compared them with those of diabetic patients(More)
During mild graded ischemia in perfused rat hearts, we (V.M. Figueredo, R. Brandes, M. W. Weiner, B. M. Massie, and S. A. Camacho. J. Clin. Invest 90: 1794-1802, 1992) previously found a relationship between decreased left ventricular developed pressure (LVDP) and increased Pi, in which intracellular pH, cytosolic Ca2+ concentration ([Ca2+]i), ATP, and(More)
We performed an experiment on adhesive strength between teeth and resin cements for porcelain laminate veneer. A compression shear test was performed using three types of resin cement in extracted human anterior teeth. In dentin, the effects of various surface treatment methods were also evaluated. All three types of resin cement showed high adhesive(More)
Glomus tumors are painful tumors that often arise at the tip of a limb. Most of these tumors occur in the dermis or subcutis, but are rarely located in the stomach, where they constitute ~2% of all benign gastric tumors [1-5]. Gastric glomus tumors are usually solitary, well-defined, submucosal lesions in the antrum, and present with a variety of symptoms,(More)