Makoto Koyama

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Although Pseudo-Relevance Feedback (PRF) is a widely used technique for enhancing average retrieval performance, it may actually hurt performance for around one-third of a given set of topics. To enhance the reliability of PRF, Flexible PRF has been proposed, which adjusts the number of pseudo-relevant documents and/or the number of expansion terms for each(More)
Serotonin 1A receptor agonists have attracted much interest recently as potential therapeutic agents for levodopa-induced motor complications, such as dyskinesia and motor fluctuations. The effects of piclozotan (SUN N4057) on a rat model of advanced Parkinson's disease were investigated. Parkinsonian rats, unilaterally 6-hydroxydopamine-lesioned rats, were(More)
Toshiba participated in the Monolingual/Bilingual tasks at NTCIR-4 CLIR using our CLIR system called BRIDJE. We submitted 24 runs covering three topic languages (Japanese, English and Chinese) and two document languages (Japanese and English) and achieved the highest performances in the E-J-D, CJ-D, C-J-T, E-E-D, J-E-D, J-E-T subtasks. We had 12 more runs(More)
Indole-3-carbinol (I3C) is a naturally occurring compound found in vegetables such as broccoli and cauliflower, and has been shown to arrest human tumor cells in the G1 phase of the cell cycle. However, the molecular mechanism responsible for this effect has not been sufficiently elucidated. We report here that I3C activates the cyclin-dependent kinase(More)
PURPOSE The clinically relevant histone deacetylase inhibitors (HDI) valproic acid (VPA) and suberoylanilide hydroxamic acid exert variable antitumor activities but increase therapeutic efficacy when combined with other agents. The natural endogenous ligand of peroxisome proliferator-activated receptor gamma 15-deoxy-Delta(12,14)-prostaglandin J(2)(More)
Toshiba participated in NTCIR-4 QAC2 Subtask 1: this is our first QAC participation. Using our newly developed Japanese QA system called ASKMi, we submitted two runs, one using Okapi/BM25 for document retrieval (TSB-A) and the other using Boolean AND constraints before applying Okapi/BM25 (TSB-B). We achieved the 5th best performance among the 17(More)
Although research in effective Question Answering (QA) has become active in recent years, it was not clear how system effectiveness affects user satisfaction in a practical QA environment. We therefore considered two practical environments in which QA may be useful (namely, Desktop and Mobile) and conducted a questionnaire survey for each environment. The(More)
The monoterpene perillyl alcohol (POH) is a naturally occurring compound derived from citrus fruits, mint and herbs. It exhibited chemotherapeutic potential against various malignant tumors in preclinical models and is currently being tested in clinical trials in patients with refractory advanced cancers. POH inhibits cellular proliferation at the G1 phase(More)
Sesamin is a major lignan constituent of sesame and possesses multiple functions such as antihypertensive, cholesterol-lowering, lipid-lowering and anticancer activities. Several groups have previously reported that sesamin induces growth inhibition in human cancer cells. However, the nature of this growth inhibitory mechanism remains unknown. The authors(More)
The INK4 family members p16(INK4a) and p15(INK4b) negatively regulate cell cycle progression by inhibition of cyclin-dependent kinase (CDK) 4/6. Loss of p16(INK4a) functional activity is frequently observed in tumor cells, and is thought to be one of the primary causes of carcinogenesis. In contrast, despite the biochemical similarity to p16(INK4a), the(More)