Makoto Koyama

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Serotonin 1A receptor agonists have attracted much interest recently as potential therapeutic agents for levodopa-induced motor complications, such as dyskinesia and motor fluctuations. The effects of piclozotan (SUN N4057) on a rat model of advanced Parkinson's disease were investigated. Parkinsonian rats, unilaterally 6-hydroxydopamine-lesioned rats, were(More)
Although Pseudo-Relevance Feedback (PRF) is a widely used technique for enhancing average retrieval performance, it may actually hurt performance for around one-third of a given set of topics. To enhance the reliability of PRF, Flexible PRF has been proposed, which adjusts the number of pseudo-relevant documents and/or the number of expansion terms for each(More)
This paper introduces a Japanese question answering system called ASKMi (Answer Seeker/Knowledge Miner). We describe its system components with an emphasis on the Question Analyzer, which performs Sematic Role Analysis for answer type recognition, query expansion and document constraint generation. Semantic Role Analysis is a rule-based,(More)
Toshiba participated in the Monolingual/Bilingual tasks at NTCIR-4 CLIR using our CLIR system called BRIDJE. We submitted 24 runs covering three topic languages (Japanese, English and Chinese) and two document languages (Japanese and English) and achieved the highest performances in the E-J-D, C-J-D, C-J-T, E-E-D, J-E-D, J-E-T subtasks. We had 12 more runs(More)
Toshiba participated in the Japanese monolingual track and the English-Japanese cross-language track at NTCIR-3, and achieved the highest retrieval performances among the DESCRIPTION runs. Our pre-submission experiments using the KIDS system fo-cused primarily on effective Japanese monolingual retrieval, and addressed several problems including term(More)
Although research in effective Question Answering (QA) has become active in recent years, it was not clear how system effectiveness affects user satisfaction in a practical QA environment. We therefore considered two practical environments in which QA may be useful (namely, Desktop and Mobile) and conducted a questionnaire survey for each environment. The(More)
Toshiba participated in NTCIR-4 QAC2 Subtask 1: this is our first QAC participation. Using our newly developed Japanese QA system called ASKMi, we submitted two runs, one using Okapi/BM25 for document retrieval (TSB-A) and the other using Boolean AND constraints before applying Okapi/BM25 (TSB-B). We achieved the 5th best performance among the 17(More)
Purpose: The clinically relevant histone deacetylase inhibitors (HDI) valproic acid (VPA) and suber-oylanilide hydroxamic acid exert variable antitumor activities but increase therapeutic efficacy when combined with other agents. The natural endogenous ligand of peroxisome proliferator–activated receptor γ 15-deoxy-Δ 12,14-prostaglandin J 2 (15d-PGJ 2) is a(More)
A new series of 1,4-benzoxazepine derivatives was designed, synthesized, and evaluated for binding to 5-HT1A receptor and cerebral anti-ischemic effect. A lot of compounds exhibited nanomolar affinity for 5-HT1A receptor with good selectivity over both dopamine D2 and alpha1-adrenergic receptors. Among these compounds,(More)
This paper describes two new features of the BRIDJE system for cross-language information access. The first feature is the partial disambiguation function of the Bi-directional Retriever, which can be used for search request translation in cross-language IR. Its advantage over a " black-box " machine translation approach is consistent across five test(More)