Makoto Katoh

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Neointimal hyperplasia is a major cause of restenosis after coronary intervention. Because vascular injury is now recognized to involve an inflammatory response, monocyte chemoattractant protein-1 (MCP-1) might be involved in underlying mechanisms of restenosis. In the present study, we demonstrate the important role of MCP-1 in neointimal hyperplasia after(More)
Prevention of restenosis after coronary intervention is a major clinical challenge, which highlights the need of new therapeutic options. Vascular injury may involve inflammatory responses that accelerate the recruitment and activation of monocytes through the activation of chemotactic factors, including monocyte chemoattractant protein-1 (MCP-1). However,(More)
Reduced activity of endothelial nitric oxide (NO) may be involved in thrombus formation on atherosclerotic plaques, a major cause of acute coronary syndrome. However, mechanisms of such increase in arterial thrombogenecity have not been fully understood. We previously reported that long-term inhibition of NO synthesis by administration of(More)
Autotaxin, also known as ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2), is a secreted enzyme that has lysophospholipase D activity, which converts lysophosphatidylcholine to bioactive lysophosphatidic acid. Lysophosphatidic acid activates at least six G-protein coupled recpetors, which promote cell proliferation, survival, migration and muscle(More)
This paper discusses the technical feasibility and ethical considerations of tuning walking training for a biped locomotion surrogate robot assisted by a device for reducing the weight load and/or a treadmill, instead of a person with a gait disorder in educational places. It is important for achieving a human-like gait that compliance of control as each(More)
We herein propose the concept of an un-fuzzy controller and present simulation results for a tank level control as an example. The proposed controller is not a fuzzy controller but is similar to a fuzzy controller with respect to both configuration and performance. Making and tuning of the controller are easier than in conventional fuzzy control because the(More)
— The present paper describes the simulation of a new intelligent transport system using a newly developed simple two-cycle case-rule-based reasoning engine (CRBRE) for double agent convoying. The CRBRE is driven by many multi-triggers (mm-triggers) and reasons through action allocation. A state transition graph-like double ring is used for the scenario(More)