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Active efflux of daunorubicin and adriamycin in sensitive and resistant sublines of P388 leukemia.
Significantly decreased uptake and retention of daunorubicin (DAU) and Adriamycin (ADR) have been reported in sublines of P388 leukemia resistant to these anthracyclines. We studied the effects of… Expand
Growth-inhibitory effect of a high glucose concentration on osteoblast-like cells.
Impaired bone formation resulting from a decline of osteoblast activity has been implicated in the pathogenesis of diabetic osteopenia. We examined the effects of high glucose concentration alone,… Expand
Expression of the neural cell adhesion molecule in astrocytic tumors
Cell adhesion molecules are among the key factors in the development of the malignant potential of brain tumors. The aim of this study was to investigate the expression of the neural cell adhesion… Expand
Evaluation of antitumor activity in a human breast tumor/nude mouse model with a special emphasis on treatment dose
Eight lines of human breast tumors implanted in nude mice were treated with various antitumor agents at two different doses, maximum tolerated doses (MTD) and rational doses (RD) that were… Expand
Thrombopoietin inhibits in vitro osteoclastogenesis from murine bone marrow cells.
To determine whether thrombopoietin (TPO) can modulate the osteoclastic differentiation from hematopoietic stem cells, we investigated the effect of TPO on in vitro osteoclastogenesis by using the… Expand
Active efflux common to vincristine and daunorubicin in vincristine-resistant P388 leukemia.
In vivo circumvention of vincristine resistance in mice with P388 leukemia using a novel compound, AHC-52.
A novel compound partially analogous to nifedipine, AHC-52, was found to sensitize multidrug-resistant tumor cells. AHC-52 at 0.5 microgram/ml completely reversed the in vitro resistance to… Expand
Effect of Tolbutamide and Glyburide on cAMP-Dependent Protein Kinase Activity in Rat Liver Cytosol
The effect of sulfonylureas tolbutamide and glyburide on adenylate cyclase– and cAMP-dependent protein kinase (A-kinase) was examined in rat liver cytosol. Both tolbutamide and glyburide inhibited… Expand
Impaired response of human osteosarcoma (MG-63) cells to human parathyroid hormone induced by sustained exposure to high glucose.
It is known that osteopenia is frequently associated with diabetes mellitus. Although its mechanism is not well understood, impaired bone formation due to an osteoblast deficit seems to be a major… Expand
Uptake and retention of adriamycin and daunorubicin by sensitive and anthracycline-resistant sublines of P388 leukemia.
Abstract Sublines of P388 leukemia completely resistant to adriamycin (P388/ADR) or daunorubicin (P388/DAU) in vivo were studied in vitro . These sublines were more resistant to the cytotoxic effects… Expand