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PURPOSE To assess the prevalence of primary open-angle glaucoma (POAG) and its association with intraocular pressure (IOP) in Tajimi City in central Japan. DESIGN A cross-sectional epidemiologic study in a defined population. PARTICIPANTS Subjects randomly selected from the population older than 40 years in Tajimi City. INTERVENTION Each subject(More)
OBJECTIVE To determine the prevalence and causes of low vision and blindness in a Japanese adult population. DESIGN Population-based cross-sectional study. PARTICIPANTS Randomly selected residents (n = 3870) of Tajimi City, Japan, who were 40 years of age or older. METHODS Of the 3021 study participants (78.1% of 3870 eligible persons), 2977 (76.9%)(More)
PURPOSE To determine the prevalence of primary angle-closure glaucoma (PACG), secondary glaucoma (SG), and all glaucoma in a Japanese population as a part of the Tajimi Study. DESIGN Population-based epidemiological survey. PARTICIPANTS A random sample of residents 40 years or older from Tajimi, Japan. INTERVENTION Each subject underwent a screening(More)
PURPOSE To compare the Pentacam to ultrasound biomicroscopy (UBM) or gonioscopy in detecting eyes with primary angle closure (PAC), including PAC suspect and PAC glaucoma. PATIENTS AND METHODS In 72 eyes of 39 Japanese with various anterior chamber angle (ACA) widths, the ACA, anterior chamber depth (ACD), and anterior chamber volume (ACV) were measured(More)
PURPOSE To determine the prevalence and risk factors for pterygium in a Japanese population aged 40 years or older on Kumejima Island, Japan. DESIGN Cross-sectional, population-based study. METHODS All residents of Kumejima Island, Japan, located in Southwestern Japan (Eastern longitude 126 degrees, 48 feet and Northern latitude 26 degrees, 20 feet),(More)
PURPOSE To identify the optimal dose of a novel Rho kinase inhibitor, K-115, by assessing dose dependency of the intraocular pressure (IOP)-lowering effects and the safety in patients with primary open-angle glaucoma or ocular hypertension. DESIGNS Multicenter, prospective, randomized, placebo-controlled, double-masked, parallel group comparison clinical(More)
IMPORTANCE Ripasudil hydrochloride hydrate (K-115), a novel rho kinase inhibitor, provides statistically significant intraocular pressure (IOP)-lowering effects and has a tolerable safety profile. However, no studies have evaluated ripasudil combined with β-blockers and prostaglandin analogues. OBJECTIVE To evaluate the additive IOP-lowering effects and(More)
Proximal renal tubular acidosis associated with ocular abnormalities such as band keratopathy, glaucoma, and cataracts is caused by mutations in the Na(+)-HCO(3)(-) cotransporter (NBC-1). However, the mechanism by which NBC-1 inactivation leads to such ocular abnormalities remains to be elucidated. By immunological analysis of human and rat eyes, we(More)
A novel automated boundary segmentation algorithm is proposed for fast and reliable quantification of nine intra-retinal boundaries in optical coherence tomography (OCT) images. The algorithm employs a two-step segmentation schema based on gradient information in dual scales, utilizing local and complementary global gradient information simultaneously. A(More)
Although intraocular pressure (IOP) is the most definitive cause of glaucoma, a subtype of open angle glaucoma (OAG) termed normal tension glaucoma (NTG), which occurs in spite of normal IOP, accounts for a large part of glaucoma cases, especially in Japan. To find common genetic variants contributing to NTG in Japanese patients, we conducted a genome-wide(More)