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Rare sugar D-allose induces specific up-regulation of TXNIP and subsequent G1 cell cycle arrest in hepatocellular carcinoma cells by stabilization of p27kip1.
TLDR
The findings surprisingly suggest that D-allose, a simple monosaccharide, may act as a novel anticancer agent via unique TXNIP induction and p27kip1 protein stabilization. Expand
Interactions of S100A2 and S100A6 with the Tetratricopeptide Repeat Proteins, Hsp90/Hsp70-organizing Protein and Kinesin Light Chain*
TLDR
The results strongly suggest that the S100 proteins modulate Hsp70-Hop-Hsp90 multichaperone complex formation and KLC-cargo interaction via Ca2+-dependent S100 protein-TPR protein complex formation in vivo as well as in vitro. Expand
Neuroprotective effect of D-psicose on 6-hydroxydopamine-induced apoptosis in rat pheochromocytoma (PC12) cells.
TLDR
The results suggest that D-psicose may play a potential role as a neuroprotective agent in the treatment of neurodegenerative diseases by inducing an up-regulation of intracellular glutathione. Expand
Regulation of nuclear localization signal‐importin α interaction by Ca2+/S100A6
TLDR
Examination of uniprotkb for S100A2 and Importin alpha binds to electrophoretic mobility supershift assay revealed no significant difference between the two isoforms. Expand
Involvement of S1P1 receptor pathway in angiogenic effects of a novel adenosine-like nucleic acid analog COA-Cl in cultured human vascular endothelial cells
TLDR
The results suggest the major contribution of S1P1 in the angiogenic effects of COA‐Cl is suggested and may lead to refinement of the design of this nucleic acid analog and ultimately to development of small molecule‐based therapeutic angiogenesis. Expand
A key role of PGC‐1α transcriptional coactivator in production of VEGF by a novel angiogenic agent COA‐Cl in cultured human fibroblasts
TLDR
COA‐Cl‐induced activation of PGC‐1α‐ERRα‐VEGF pathway has a potential as a novel means for therapeutic angiogenesis. Expand
Synthesis and Evaluation of Novel Carbocyclic Oxetanocin A (COA-Cl) Derivatives as Potential Tube Formation Agents.
TLDR
Six novel carbocyclic oxetanocin A analogs with various hydroxymethylated or spiro-conjugated cyclobutane rings at the N(9)-position of the 2-chloropurine moiety showed good to moderate activity with angiogenic potency and may be important for further development of this class of compounds as potential tube formation agents. Expand
Synthesis and Evaluation of Novel Cyclopropane Nucleoside as Potential Tube Formation Agents.
TLDR
Five novel nucleoside analogs with mono or bis-hydroxymethylated cyclopropane rings at the N9-position of the 2-chloroadenine moiety (2-chloro-carbocyclic oxetanocin A [COA-Cl] analog) showed good to moderate activity with angiogenic potency. Expand
COA-Cl induces dopamine release and tyrosine hydroxylase phosphorylation: In vivo reverse microdialysis and in vitro analysis
TLDR
The results provide the first evidence that COA-Cl can stimulate dose-dependent DA release and activation of TH phosphorylation, suggesting that COa-Cl may be a promising therapeutic candidate for the treatment of neurological dysfunction associated with low DA. Expand
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