Majken Nielsen

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Type 1 diabetes mellitus (T1DM) is caused by specific destruction of the pancreatic beta cells in the islets of Langerhans. Increased sensitivity to cytokines, in particular to interleukin-1β (IL-1β) seems to be an acquired trait during beta-cell maturation. In response to cytokines both protective and deleterious mechanisms are induced in beta cells, and(More)
The 2 major metabolites of norepinephrine (NE), 3,4-dihydroxyphenylglycol-sulphate (DOPEG-SO4) and free plus conjugated 3-methoxy-4-hydroxyphenylglycol (total-MOPEG), both their endogenous concentrations and their accumulation from the NE-precursors 3H-tyrosine or 3H-dopamine, were determined in the whole rat brain to assess the effect of chronic treatment(More)
The O-methylated and non-O-methylated end metabolites of norepinephrine (NE) in the rat brain were measured to investigate a presumed shift in metabolism of NE from intra- to extraneuronal metabolism by uptake inhibitory antidepressant drugs. Desipramine (DMI), protriptyline and maprotiline in doses from 2.5–20 mg/kg reduced the concentration of the major(More)
3H-l-Dopa was given to rats after a peripheral decarboxylase inhibitor Ro 4-4602 (50 mg/kg) and the effect of 30 min pretreatment with amitriptyline (10 mg/kg), desipramine (10 mg/kg) and imipramine (10 mg/kg) on the brain formation of 3H-dopamine, 3H-noradrenaline and their major metabolites was investigated. Desipramine produced a decrease in the level of(More)
3H-l-Dopa was given intraperitoneally, after a peripheral decarboxylase inhibitor Ro 4-4602 (50 mg/kg), to male Wistar rats and the effect of protriptyline pretreatment (10 mg/kg, 30 min) on the formation and metabolism of the brain 3H-catecholamines, dopamine and noradrenaline and all their metabolites was investigated. Protriptyline produced a strong(More)
Aims/hypothesis. Both patients with Type II (non-insulin-dependent) diabetes mellitus and normoglycaemic, insulin resistant subjects were shown to have an increased lipid content in skeletal muscle, which correlates negatively with insulin sensitivity. Recently, it was shown that during a hyperinsulinaemic euglycaemic clamp interstitial glycerol was reduced(More)
Acute unilateral obstruction (UUO) of the pig kidney is associated with an increased secretion of intrarenally generated angiotensin II (ANG II). In order to clarify the importance of this intrarenal ANG II generation during acute UUO, ipsilateral and contralateral renal blood flow and renal secretion rate of ANG II were determined in pigs during continuous(More)
Wound infection, defined as accumulation of pus draining spontaneously or after opening of the Wound, developed in 19 out of 22 guinea pigs (86 %) after intraincisional contamination with 107 Escherichia coli plus 108 Bacteroides fragilis before wound closure. Antibiotic prophylaxis with gentamicin plus clindamycin significantly reduced the wound sepsis(More)
The aim of the present study was to investigate whether prenatal exposure to the suspected estrogenic compound 4-tert-octylphenol (OP), influences oocyte number in newborn female mice. In addition, effects on the percentage distribution of prefollicular, follicular, and atretic oocytes were investigated. Pregnant mice were subcutaneously injected with OP (1(More)