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BACKGROUND Chronic obstructive pulmonary disease (COPD) is a epidemic disease which is mainly due to cigarette smoking. The effect of carvacrol on systemic inflammation in guinea pig model of COPD was examined in the present study. METHODS Guinea pigs of both sexes were divided into 6 groups, including: control, COPD, COPD+drinking water containing three(More)
OBJECTIVES Analgesic effects of oxytocin and it's the other physiological effects were well-known. The aim of present study was determination of nitric oxide role on analgesic effects of oxytocin in mice. MATERIALS AND METHODS 216 male Albino mice were divided randomly into two experimental groups, tail flick and formalin test. Each experimental group(More)
1 Neurogeneeic Inflammation Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran, 2 Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran, 3 Department of Immunology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran, 4 Immunology of Infectious Diseases Research Center,(More)
The effect of the extract of Zataria multiflora (Z. multiflora) on IFN-γ, FOXP3, IL-4, TGF-β, and IL-17 gene expression was evaluated in cultured splenocytes obtained from control, nontreated asthma or sensitized mice (group S), Sensetized animals treated with dexamethasone or three concentrations of Z. multiflora extract (200, 400 and 800 μg/ml) (n = 6,(More)
OBJECTIVES With regard to pharmacological effects of carvacrol on the respiratory system, its effect on cytokines genes expression in splenocytes of asthmatic mice was examined in this study. MATERIALS AND METHODS Splenocytes were isolated from non-sensitized (control group), sensitized mice to ovalbumin (OVA) (group S), and S animals treated with(More)
Sickle cell disease (SCD) is an inherited autosomal recessive disorder. We aimed to describe the spectrum of haplotypes of BS-gene and to investigate a relationship with disease phenotype in patients with SCD in Southern Iran. We didn’t find any significant association between BS-globin gene haplotypes and clinical severity of the disease in an Iranian(More)
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