Maja Skataric

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An ubiquitous property of biological sensory systems is adaptation: a step increase in stimulus triggers an initial change in a biochemical or physiological response, followed by a more gradual relaxation toward a basal, pre-stimulus level. Adaptation helps maintain essential variables within acceptable bounds and allows organisms to readjust themselves to(More)
The phenomenon of fold-change detection, or scale-invariance, is exhibited by a variety of sensory systems, in both bacterial and eukaryotic signalling pathways. It has been often remarked in the systems biology literature that certain systems whose output variables respond at a faster time scale than internal components give rise to an approximate(More)
— The property termed scale-invariance, or fold-change detection, represents a phenomenon that is observed in a variety of biological systems, ranging from bacterial to eukaryotic signaling pathways. Mathematically, it represents invariance of the complete output trajectory with respect to a rescaling of input magnitudes. In the systems biology literature,(More)
— This paper makes some remarks concerning model-based estimation methods for the rate of a nonhomo-geneous Poisson processes that describes events arising from modeling biological phenomena in which discrete events are measured. We describe an approach based on observers and Kalman filters as well as preliminary simulation results, and compare these to(More)
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