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  • Stéphanie Dulucq, Stéphane Bouchet, +6 authors François-Xavier Mahon
  • Medicine
  • Blood
  • 2008 (First Publication: 1 September 2008)
  • Despite the excellent efficacy of imatinib in chronic myeloid leukemia (CML), the response in patients is heterogeneous, which may in part be caused by pharmacogenetic variability. Imatinib has beenContinue Reading
  • Maja Krajinovic, Parviz Ghadirian, +6 authors Daniel Sinnett
  • Medicine
  • International journal of cancer
  • 2001 (First Publication: 15 April 2001)
  • Breast cancer is the most frequent malignancy among women. Since genetic factors such as BRCA1 and BRCA2 as well as reproductive history constitute only 30% of the cause, environmental exposure mayContinue Reading
  • Maja Krajinovic, Hugues Sinnett, Chantal Richer, Damian Labuda, Daniel Sinnett
  • Biology, Medicine
  • International journal of cancer
  • 2002 (First Publication: 10 January 2002)
  • Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. The genetic factors underlying the susceptibility to this disease remain elusive. The enzymes CYP2E1, MPO and NQO1 are involvedContinue Reading
  • Caroline Laverdière, Sonia Chiasson, Irina Costea, Albert Moghrabi, Maja Krajinovic
  • Medicine
  • Blood
  • 2002 (First Publication: 15 November 2002)
  • Methotrexate (MTX) is a key compound of chemotherapeutic regimens used in the treatment of childhood acute lymphoblastic leukemia (ALL). Resistance to this drug may arise by, among other factors,Continue Reading
  • Francesco Ceppi, Chloé Langlois-Pelletier, +12 authors Maja Krajinovic
  • Medicine, Biology
  • Pharmacogenomics
  • 2014 (First Publication: 1 August 2014)
  • BACKGROUND Vincristine (VCR) is a standard component in the treatment of childhood acute lymphoblastic leukemia (ALL). VCR cytotoxicity is primarily due to its ability to disrupt the formation ofContinue Reading
  • Maja Krajinovic, Chantal Richer, Hugues Sinnett, Damian Labuda, Donna Sinnett
  • Biology, Medicine
  • Cancer epidemiology, biomarkers & prevention : a…
  • 2000 (First Publication: 1 June 2000)
  • Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. In utero and postnatal exposures to various carcinogens may play a role in the etiology of this disease. N-acetyltransferases,Continue Reading
  • Maja Krajinovic, Damian Labuda, +4 authors Daniel Sinnett
  • Biology, Medicine
  • Clinical cancer research : an official journal of…
  • 2002 (First Publication: 1 March 2002)
  • PURPOSE The most common childhood malignancy, acute lymphoblastic leukemia (ALL), remains the leading cause of cancer-related death in children because of resistant cases in which underlyingContinue Reading