Maj Halling Thomsen

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OBJECTIVE To determine serum amyloid A (SAA) concentrations in serum and synovial fluid from healthy horses and horses with joint disease and assess the effect of repeated arthrocentesis on SAA concentrations in synovial fluid. Animals-10 healthy horses and 21 horses with various types of joint disease. PROCEDURES Serum and synovial fluid samples were(More)
This study aimed to create an evidence base for detection of stance-phase timings from motion capture in horses. The objective was to compare the accuracy (bias) and precision (SD) for five published algorithms for the detection of hoof-on and hoof-off using force plates as the reference standard. Six horses were walked and trotted over eight force plates(More)
OBJECTIVE To compare the analgesic effect of intra-articular (IA) and intravenous (IV) morphine in horses with experimentally induced synovitis. ANIMALS Eight adult horses. STUDY DESIGN Randomized, observer blinded, double dummy trial with sequential crossover design. METHODS Radiocarpal synovitis was induced by IA injection of lipopolysaccharide on(More)
REASONS FOR PERFORMING STUDY Equine lameness examination is based on subjective visual scoring of lameness. Instrumented objective methods for lameness examinations may be complicated to perform and the equipment is often stationary. Accelerometry has a potential clinical use; however, the reduction and interpretation of equine accelerometric data are not(More)
To establish a pharmacokinetic model for the model drug, sodium diatrizoate (DTZ), allowing joint disappearance kinetics to be estimated from serum appearance kinetics following intra-articular administration, and to calculate the relative joint exposure after intravenous and intra-articular DTZ administration (Fiv/IA). Each of five horses received an(More)
OBJECTIVE To compare the effects of intra-articular (IA) versus IV administration of morphine on local and systemic inflammatory responses in horses with experimentally induced acute synovitis. ANIMALS 8 horses. PROCEDURES Each horse received the following 2 treatments 4 hours after synovitis was induced: IA administration of morphine (0.05 mg/kg) with(More)
The objective of the present study was to explore the potential of using an in situ suspension forming drug delivery system of celecoxib to provide sustained drug exposure in the joint cavity following intra-articular administration. In vitro, precipitates were formed upon addition of a 400 mg/mL solution of celecoxib in polyethylene glycol 400 (PEG 400) to(More)
OBJECTIVE To describe the pharmacokinetics of intra-articularly (IA) administered morphine. STUDY DESIGN Experimental randomized, cross-over study. ANIMALS Eight adult healthy mixed breed horses aged 6.5 +/- 2.3 (mean +/- SD) years and weighing 535 +/- 86 kg. METHODS Unilateral radiocarpal synovitis was induced by IA injection of 3 microg(More)
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