Mainul Hossain

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This paper describes a nanoparticle enhanced X-ray irradiation based strategy that can be used to kill multidrug resistant (MDR) bacteria. In the proof-of-concept experiment using MDR Pseudomonas aeruginosa (P. aeruginosa) as an example, polyclonal antibody modified bismuth nanoparticles are introduced into bacterial culture to specifically target P.(More)
Traditional in vitro nanotoxicity researches are conducted on cultured two-dimensional (2D) monolayer cells and thereby cannot reflect organism response to nanoparticle toxicities at tissue levels. This paper describes a new, high-throughput approach to test in vitro nanotoxicity in three-dimensional (3D) microtissue array, where microtissues are formed by(More)
Nanoparticles of high atomic number (Z) materials can act as radiosensitizers to enhance radiation dose delivered to tumors. An analytical approach is used to calculate dose enhancements to tumor endothelial cells and their nuclei for a series of nanoparticles (bismuth, gold and platinum) located at different locations relative to nuclei by considering(More)
This paper describes a novel thermal biosensing technique for the highly sensitive and selective detection of thrombin using RNA aptamer-functionalized phase change nanoparticles as thermal probes. The presence of thrombin in solution leads to attachment of nanoparticles onto a substrate modified with the same aptamer by forming sandwiched complexes. The(More)
This paper describes in vitro cytotoxicity of bismuth nanoparticles revealed by three complementary assays (MTT, G6PD, and calcein AM/EthD-1). The results show that bismuth nanoparticles are more toxic than most previously reported bismuth compounds. Concentration dependent cytotoxicities have been observed for bismuth nanoparticles and surface modified(More)
The early detection and eradication of circulating tumor cells (CTCs) play an important role in cancer metastasis management. This paper describes a new nanoparticle-enabled technique for integrated enrichment, detection and killing of CTCs by using magnetic nanoparticles and bismuth nanoparticles, X-ray fluorescence spectrometry, and X-ray radiation. The(More)
Analytical and Monte Carlo simulations have been used to predict dose enhancement factors in nanoparticle-enhanced X-ray radiation therapy. Both simulations predict an increase in dose enhancement in the presence of nanoparticles, but the two methods predict different levels of enhancement over the studied energy, nanoparticle materials, and concentration(More)
This paper describes a new type of silica microspheres that contain a panel of phase change nanoparticles (Field's alloy, indium, tin or lead-tin eutectic alloy). The thermophysical properties of solid-liquid phase change nanoparticles, i.e., composition-dependent melting temperatures, sharp melting peaks, and large thermal scan range, allow construction of(More)
Test coverage is an important metric of software quality, since it indicates thoroughness of testing. A fundamental problem of software testing is how to achieve higher coverage faster, and it is a difficult problem since it requires testers to cleverly pinpoint test input data to steer execution sooner toward application code that contains more statements.(More)
This paper reports an image-based, on-chip microtissue radiation biodosimeter that can simultaneously monitor radiation responses of multiple mammalian cell types. The microtissue chip is fabricated by molding molten agarose gel onto microfabricated patterns to form microwells, and seeding a variety of cell suspensions into different microwells inside the(More)