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R loops are transcription byproducts that constitute a threat to genome integrity. Here we show that R loops are tightly linked to histone H3 S10 phosphorylation (H3S10P), a mark of chromatin… (More)
R-loops are harmful structures with a negative impact on transcription and recombination during mitosis, but no information exists for meiosis. We used Saccharomyces cerevisiae and Caenorhabditis… (More)
THO is a conserved eukaryotic complex involved in mRNP biogenesis and RNA export that plays an important role in preventing transcription- and RNA-mediated genome instability in mitosis and meiosis.… (More)
[This corrects the article DOI: 10.1371/journal.pone.0052447.].
Poster presentado en EMBO Workshop on Recombination Mechanism and Genome Instability, celebrado en Jerez de la Frontera (Espana) del 21 al 25 de mayo de 2012
Coordination of DNA replication with DNA-damage sensing, repair, and cell cycle progression ensures with high probability genome integrity during cell divisions, thus preventing mutations and DNA… (More)