Maik Liebl

  • Citations Per Year
Learn More
Due to their special physicochemical properties, iron nanoparticles offer new promising possibilities for biomedical applications. For bench to bedside translation of super-paramagnetic iron oxide nanoparticles (SPIONs), safety issues have to be comprehensively clarified. To understand concentration-dependent nanoparticle-mediated toxicity, the exact(More)
Meaningful applications of magnetic nanoparticles (MNP) in biomedicine require the ability to quantify MNP in a variety of environments and biological materials (cells, tissue, and organs). Here we describe a method for the integral, noninvasive quantification of MNP. Our method is based on magnetorelaxometry (MRX), it relies on the detection of their(More)
Magnetorelaxometry (MRX) is a well-known measurement technique which allows the retrieval of magnetic nanoparticle (MNP) characteristics such as size distribution and clustering behavior. This technique also enables the non-invasive reconstruction of the spatial MNP distribution by solving an inverse problem, referred to as MRX imaging. Although MRX allows(More)
BACKGROUND Quantitative knowledge about the spatial distribution and local environment of magnetic nanoparticles (MNPs) inside an organism is essential for guidance and improvement of biomedical applications such as magnetic hyperthermia and magnetic drug targeting. Magnetorelaxometry (MRX) provides such quantitative information by detecting the magnetic(More)
New therapies against cancer based on magnetic nanoparticles (MNPs) require a quantitative spatially resolved imaging of MNPs inside a body. In magnetorelaxometry (MRX), a distribution of nanoparticles can be quantified non-invasively by measuring its relaxation after removal of an external magnetizing field. Conventionally, in MRX the sample is exposed to(More)
  • 1