Maia Sephashvili

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Homocysteine is a sulfur-containing, nonproteinogenic, neurotoxic amino acid biosynthesized during methyl cycles after demethylation of S-adenosylmethionine (SAM) to S-adenosylhomocysteine (SAH) and subsequent hydrolysis of SAH into homocysteine and adenosine. Formed homocysteine is either catabolized into cystathionine (transsulfuration pathway) by(More)
These experiments examined the release of glutamate (Glu) and GABA in the hippocampus of memantine (2,5mg/kg, i.p. for four weeks) or saline treated rats prior to, during, and after spontaneous alternation test. Glu and GABA release during the 10 min samples taken at the time of the behavioral testing of memantine or saline treated animals were not(More)
The present study investigated spatial working memory assessed in spontaneous alternation (SA) task and hippocampal glutamate and GABA release prior to, during, and after SA test in sham-operated and electrolytic medial septal (MS) lesioned rats. Also, have been investigated the effects of MS lesion on KCl-stimulated release of glutamate and GABA in the(More)
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