Maia McFadden

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We have conducted a phase I study of the cyclic peptide echinomycin (Quinomycin A) on a schedule of administration of once every 4 weeks. Ten dose levels between 20 and 1800 micrograms/m2 were studied. Acute gastrointestinal toxicity, thrombocytopenia, and transient elevations of serum transaminases occurred at doses of greater than or equal to 1000(More)
Cortical somatosensory evoked potential (CSEP), spinal somatosensory evoked potential (SSEP), and electroencephalogram were recorded in rats under pentobarbital anesthesia. After baseline recordings in room air (21% O2), animals were subjected to a graded hypoxia at 15.75%, 10.5%, and 5.25% oxygen levels for 10 minutes. Each level of hypoxia was followed by(More)
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