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The evolution of influenza A virus is linked to a non-fixed evolutionary landscape driven by tight co-evolutionary interactions between hosts and influenza strains. Herd-immunity, cross-immunity and age-structure are among the factors shown to support the coexistence of multiple strain oscillations. In this study, we incorporate two influenza strains and(More)
Spatial heterogeneity plays an important role in the distribution and persistence of infectious diseases. In this article, a vector-host epidemic model is proposed to explore the effect of spatial het-erogeneity on the evolution of vector-borne diseases. The model is a Ross-McDonald type model with multiple competing strains on a number of patches connected(More)
A classical epidemiological framework is used to provide a preliminary cost analysis of the effects of quarantine and isolation on the dynamics of infectious diseases for which no treatment or immediate diagnosis tools are available. Within this framework we consider the cost incurred from the implementation of three types of dynamic control strategies.(More)
Low Pathogenic Avian Influenza (LPAI) virus, which circulates in wild bird populations in mostly benign form, is suspected to have mutated into a highly pathogenic (HPAI) strain after transmission to the domestic birds. HPAI has recently garnered worldwide attention because of the " spillover " infection of this strain from domestic birds to(More)
In this paper, a two-strain model that links immunological and epidemiological dynamics across scales is formulated. On the within-host scale, the two strains eliminate each other with the strain with the larger immunological reproduction persisting. However, on the population scale superinfection is possible, with the strain with larger immunological(More)
Please cite this article in press as: H.-M. Wei et al., An epidemic model of a vector-borne disease with direct transmission and time delay, J. Abstract This paper considers an epidemic model of a vector-borne disease which has direct mode of transmission in addition to the vector-mediated transmission. The incidence term is assumed to be of the bilinear(More)
Mathematical models developed for studying malaria dynamics often focus on a single, homogeneous population. However, human movement connects environments with potentially different malaria transmission characteristics. To address the role of human movement and spatial heterogeneity in malaria transmission and malaria control, we consider a simple malaria(More)
The recent approval of a rotavirus vaccine in Mexico motivates this study on the potential impact of the use of such a vaccine on rotavirus prevention and control. An age-structured model that describes the rotavirus transmission dynamics of infections is introduced. Conditions that guarantee the local and global stability analysis of the disease-free(More)