Mai S. Mabrouk

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Lung cancer is the most common cancer which leads to death for both women and men, so the early detection of lung cancer increases the therapy success. Different techniques are used to provide the early detection such as Computer Aided Detection (CAD) system. In this paper, we present an automatic Computer Aided Detection (CAD) system to detect a large lung(More)
Genetics of autoimmune diseases represent a growing domain with surpassing biomarker results with rapid progress. The exact cause of Rheumatoid Arthritis (RA) is unknown, but it is thought to have both a genetic and an environmental bases. Genetic biomarkers are capable of changing the supervision of RA by allowing not only the detection of susceptible(More)
Rheumatoid arthritis (RA) is an autoimmune disease which has a significant socio-economic impact. The aim of the current study was to investigate eight candidate RA susceptibility loci to identify the associated variants in Egyptian population. Eight single nucleotide polymorphisms (SNPs) (MTHFR-C677T and A1298C, TGFβ1 T869C, TNFB A252G, and VDR-ApaI, BsmI,(More)
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality worldwide. New insights into the pathogenesis of this lethal disease are urgently needed. Chromosomal copy number alterations (CNAs) can lead to activation of oncogenes and inactivation of tumor suppressors in human cancers. Thus, identification of cancer-specific CNAs(More)
Diabetes and chronic liver disease (CLD) are common long-term conditions in the developed and developing world. Patients with liver disease have been continuously increasing because of excessive consumption of alcohol, inhale of harmful gases, intake of contaminated food, pickles and drugs. The liver has many essential functions, and liver disease presents(More)
Protein structure prediction is one of the most important problems in bioinformatics. Protein's secondary structure prediction is a key step in prediction of three-dimensional structure of protein. Despite all the efforts made, so far finding an accurate computational approach to solving a protein structure problem remains a challenging problem. Many(More)
Breast cancer continues to be a significant public health problem in the world. Early detection is the key for improving breast cancer prognosis. Mammogram breast X-ray is considered the most reliable method in early detection of breast cancer. However, it is difficult for radiologists to provide both accurate and uniform evaluation for the enormous(More)
In Bioinformatics, Motif Finding is defined as the ability to locate repeated patterns in the sequence of nucleotides or amino acids. Identifying these motifs in DNA sequences is a computationally hard problem which requires efficient algorithms. Cuckoo search (CS) is a new promising metaheuristic search algorithm , CS has been inspired by the breeding(More)