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Mitochondrial ATP synthase residue betaarginine-408, which interacts with the inhibitory site of regulatory protein IF1, is essential for the function of the enzyme.
Results indicate that betaArg408 is essential not for assembly of the F(1)F(0) complex but for the catalytic activity of the enzyme.
20-Deoxy-20-fluorocamptothecin: Design and Synthesis of Camptothecin Isostere
20-Deoxy-20-fluorocamptothecin (2) has been synthesized as an isosteric analogue of camptothecin (1). The use of select-fluor or N-fluorobenzenesulfonimide for the electrophilic fluorination of