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Identification of a novel long-acting 4'-modified nucleoside reverse transcriptase inhibitor against HBV.
Development of New Low-GWP Refrigerants–Refrigerant Mixtures Including HFO-1123
- Mai Hashimoto, T. Otsuka, R. Akasaka
- EngineeringScience and Technology for the Built Environment
- 3 July 2019
New refrigerants with low global warming potential (GWP) are currently being developed to replace conventional higher GWP refrigerants. Recently, we have developed binary and ternary refrigerant…
Further Evidence Regarding the Important Role of Chlorine Atoms of Aripiprazole on Binding to the Site II Area of Human Albumin.
Effect of Repeated Injections of Adenosine Diphosphate-Encapsulated Liposomes Coated with a Fibrinogen γ-Chain Dodecapeptide Developed as a Synthetic Platelet Substitute on Accelerated Blood…
- K. Taguchi, Mai Hashimoto, T. Maruyama
- Biology, MedicineJournal of pharmaceutical sciences
- 1 September 2015
It is concluded that the repeated injection of H12-(ADP)-liposome treatment in rat model with anticancer drug-induced thrombocytopenia did not induce the ABC phenomenon, which involves a loss in the long-circulation half-life of the material when administered repeatedly to the same animals.
Pharmacokinetics studies of 4′‐cyano‐2′‐deoxyguanosine, a potent inhibitor of the hepatitis B virus, in rats
- Mai Hashimoto, K. Taguchi, M. Otagiri
- Biology, ChemistryThe Journal of pharmacy and pharmacology
- 1 June 2018
An analytical method for quantitatively determining CdG levels in biological samples by liquid chromatography–mass spectrometry (LC/MS) and to investigate the pharmacokinetic properties of CdGs in rats after intravenous and oral administration are developed.
Pharmacokinetic properties of a novel inosine analog, 4′-cyano-2′-deoxyinosine, after oral administration in rats
The results suggest that the SK14-061a has favorable pharmacokinetic properties with a high bioavailability with the potential for use in oral pharmaceutical formulations, but drug-drug interactions should also be considered.
Interaction of Aripiprazole with Human α1-Acid Glycoprotein.
Effects of Oxidation of Human Serum Albumin on the Binding of Aripiprazole.
- Keiki Sakurama, K. Nishi, V. Chuang, Mai Hashimoto, K. Yamasaki, M. Otagiri
- Biology, ChemistryBiological & pharmaceutical bulletin
- 1 June 2020
The results indicate that prepared HSAs are mildly oxidized and well reflects the status of HSA during chronic diseases, however, oxidized HSAs were observed to have a significant decrease in binding to ARP, and oxidation of H SA during chronic disease state significantly affected the microenvironment for ARP.
Pharmacokinetic Properties of Orally Administered 4'-Cyano-2'-deoxyguanosine, a Novel Nucleoside Analog Inhibitor of the Hepatitis B Virus, in Viral Liver Injury Model Rats.
- Mai Hashimoto, K. Taguchi, Shuhei Imoto, K. Yamasaki, H. Mitsuya, M. Otagiri
- Biology, MedicineBiological & pharmaceutical bulletin
- 1 September 2020
The results suggest that liver pathology has only a minor effect on the pharmacokinetic properties of CdG, but the influence of food on C dG absorption needs to be considered.
A Safety Evaluation Study in Mice Revealed that Albumin Dimer is Safe for Medical and Pharmaceutical Applications
The results obtained here indicate HSA dimer is safe and should be useful for medical and pharmaceutical applications and plasma clinical chemistry and histological examinations indicate that the HSADimer has no deleterious effect on liver and renal functions.