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Protective effects of atorvastatin and quercetin on isoprenaline-induced myocardial infarction in rats
Abstract Myocardial infarction (MI) continues to be a major public health problem in the world. Statins exhibit cardio-protective effects by several mechanisms beyond their lipid lowering activity.… Expand
Eicosapentaenoic Acid and Vitamin E Against Doxorubicin Induced Cardiac and Renal Damages: Role of Cytochrome c and iNOS.
BACKGROUND The current study aimed to evaluate the mechanisms involved in protection against doxorubicin-induced cardiac and renal toxicities upon treatment with eicosapentaenoic acid and vitamin E.… Expand
Pyrrolidinedithiocarbamate attenuates bleomycin-induced pulmonary fibrosis in rats: Modulation of oxidative stress, fibrosis, and inflammatory parameters
- Mai A Zaafan, Hala F Zaki, Amany I. El-Brairy, Sanaa A Kenawy
- Experimental lung research
- 31 October 2016
ABSTRACT Objective: The current study aimed to investigate the modulatory effects of pyrrolidinedithiocarbamate (PDTC; 100 mg/kg) on bleomycin-induced pulmonary fibrosis (5 mg/kg; intratracheal) in… Expand
The protective effect of Korean Red Ginseng against rotenone-induced Parkinson's disease in rat model: modulation of nuclear factor-κβ and caspase-3.
- Mai A Zaafan, Amr M Abdelhamid, Sherine M Ibrahim
- Medicine, Biology
- Current pharmaceutical biotechnology
OBJECTIVE Korean red ginseng was reported to have many biological effects like the antioxidant and the anti-inflammatory activities. Oxidative stress and neuro-inflammation play major roles in the… Expand
Amitriptyline attenuates bleomycin-induced pulmonary fibrosis: modulation of the expression of NF-κβ, iNOS, and Nrf2
- Mai A Zaafan, Ahmed R. Haridy, A. Abdelhamid
- Chemistry, Medicine
- Naunyn-Schmiedeberg's Archives of Pharmacology
- 1 March 2019
Amitriptyline is a tricyclic antidepressant that was suggested to have antifibrotic potential. The current study aimed to investigate the modulatory effects of amitriptyline on bleomycin-induced… Expand
Isoprenaline-Induced Myocardial Infarction in Rats: Protective Effects of Hesperidin
Myocardial infarction is amongst the most common causes of death worldwide. The present study aimed to investigate the cardioprotective effect of hesperidin (200 mg/kg) either individually or in… Expand
Association of Chemerin rs17173608 and Vaspin rs2236242 Polymorphisms with Type Two Diabetes Mellitus and its Impact on their Corresponding Serum Levels in Egyptian Population
Type-2 diabetes mellitus (T2DM) is an endocrine disease having a significant genetic component.