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Cross-linking of the surface receptor with high affinity for IgE (Fc epsilonRI) by multivalent antigen/immunoglobulin E complexes, as well as aggregation of Thy-1 glycoprotein by monoclonal antibodies lead in rat basophilic leukemia cells, clone RBL-2H3, to tyrosine phosphorylation of several cellular proteins, followed by a release of secretory components.(More)
The glycosyl-phosphatidylinositol (GPI)-anchored glycoprotein Thy-1 is one of the most abundant molecules expressed on the surface of rat mast cells and rat basophilic leukemia (RBL) cells. The finding that Thy-1 from detergent-solubilized RBL-2H3 cells forms complexes with src-related protein-tyrosine kinase p56/p53lyn suggested that this kinase may play a(More)
Activation of rat mast cells through the receptor with high affinity for IgE (Fc epsilonRI) requires a complex set of interactions involving transmembrane subunits of the Fc epsilonRI and two classes of nonreceptor protein tyrosine kinase (PTK). the Src family PTK p53/p56(lyn) (Lyn) and the Syk/ZAP-family PTK p72(syk) (Syk). Early activation events involve(More)
Designing modern circuits comprised of millions of gates is a very challenging task. Therefore new directions are investigated for efficient modeling and verification of such systems. Recently, a new language, SystemVerilog, was introduced and became an IEEE standard. SystemVerilog extends the hardware description language Verilog by including higher(More)
iii ACKNOWLEDGEMENTS So many faculty members, persons, and students helped and influenced my work at Southern Methodist University. First, I gratefully acknowledge Dr. Mitchell A. Thornton, my dissertation advisor, for his guidance, encouragement and support throughout the research phase of this dissertation. Without him, I would not have been able to(More)
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