Mahrokh Tohidi

Learn More
3′-Amino-3′-deoxyguanosine-5′-phosphorimidazolidate (ImpGnh 2) oligomerizes more rapidly and regiospecifically than related nucleotide derivatives on a d(CpCpCpCpC) template. The greater nucleophilicity of the amino group leads to efficient oligomerization even when the structure of the double-helical complex formed by the template and the substrate is not(More)
Bismonophosphoimidazolides of acyclic analogues of guanosine IV and adenosine V were synthesized. They undergo oligomerization in the presence of complementary polynucleotide templates. Details of their synthesis and their subsequent template-and nontemplate-directed reactions are described, and their possible relevance to the origin of life is discussed.
When 2′-deoxythymidine-3′,5′-cyclic diphosphate, or the cyclic pyrophosphates of the acyclic nucleoside analogues II and IV are heated to 65–85°C in the presence of imidazole, oligomers with lengths up to 20–30 are formed in excellent yield. This reaction provides a useful source of oligomers for use as templates in aqueous condensation reactions. In the(More)
  • 1