Mahmud Hossain

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Sensitive detection of low-abundance proteins in complex biological samples has typically been achieved by immunoassays that use antibodies specific to target proteins; however, de novo development of antibodies is associated with high costs, long development lead times, and high failure rates. To address these challenges, we developed an antibody-free(More)
Selected reaction monitoring mass spectrometry (SRM-MS) is playing an increasing role in quantitative proteomics and biomarker discovery studies as a method for high throughput candidate quantification and verification. Although SRM-MS offers advantages in sensitivity and quantification compared with other MS-based techniques, current SRM technologies are(More)
Selected reaction monitoring (SRM)-MS is an emerging technology for high throughput targeted protein quantification and verification in biomarker discovery studies; however, the cost associated with the application of stable isotope-labeled synthetic peptides as internal standards can be prohibitive for screening a large number of candidate proteins as(More)
Interest in the application of advanced proteomics technologies to human blood plasma- or serum-based clinical samples for the purpose of discovering disease biomarkers continues to grow; however, the enormous dynamic range of protein concentrations in these types of samples (often >10 orders of magnitude) represents a significant analytical challenge,(More)
Recently, selected reaction monitoring mass spectrometry (SRM-MS) has been more frequently applied to measure low abundance biomarker candidates in tissues and biofluids, owing to its high sensitivity and specificity, simplicity of assay configuration, and exceptional multiplexing capability. In this study, we report for the first time the development of(More)
The Internet of Vehicles (IoV) is a complex and dynamic mobile network system that enables information sharing between vehicles, their surrounding sensors, and clouds. While IoV opens new opportunities in various applications and services to provide safety on the road, it introduces new challenges in the field of digital forensics investigations. The(More)
In recent years, the concept of the Internet of Things (IoT) has already been implemented in numerous application domains, such as smart city, intelligent healthcare assistant, and smart transportation management. Researchers or developers associated with these domains frequently require diverse types of IoT devices to implement or test their IoT related(More)
The Internet of Things (IoT) devices perform security-critical operations and deal with sensitive information in the IoT-based systems. Therefore, the increased deployment of smart devices will make them targets for cyber attacks. Adversaries can perform malicious actions, leak private information, and track devices' and their owners' location by gaining(More)
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