Mahmoud Moradi

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Since its discovery in 1979, left-handed Z-DNA has evolved from an in vitro curiosity to a challenging DNA structure with crucial roles in gene expression, regulation and recombination. A fundamental question that has puzzled researchers for decades is how the transition from B-DNA, the prevalent right-handed form of DNA, to Z-DNA is accomplished. Due to(More)
The main objective of this paper is to study the complementarity nature of enterprise modeling and knowledge management within the framework of enterprises. To do so, we evaluate some important methodologies in each domain and then several modeling points of view are explained. By reviewing CommonKADS, MASK, CIMOSA, and GIM methodologies and their modeling(More)
Active transport of materials across the cellular membrane is one the most fundamental processes in biology. In order to accomplish this task, membrane transporters rely on a wide range of conformational changes spanning multiple time and size scales. These molecular events govern key functional aspects in membrane transporters, namely, coordinated gating(More)
The potassium channel KcsA offers a unique opportunity to explicitly study the dynamics of the moving parts of ion channels, yet our understanding of the extent and dynamic behavior of the physiologically relevant structural changes at the inner gate in KcsA remains incomplete. Here, we use electron paramagnetic resonance, nuclear magnetic resonance, and(More)
We have characterized the conformational ensembles of polyglutamine Qn peptides of various lengths n (ranging from 6 to 40), both with and without the presence of a C-terminal polyproline hexapeptide. For this, we used state-of-the-art molecular dynamics simulations combined with a novel statistical analysis to characterize the various properties of the(More)
Characterizing large-scale structural transitions in biomolecular systems poses major technical challenges to both experimental and computational approaches. On the computational side, efficient sampling of the configuration space along the transition pathway remains the most daunting challenge. Recognizing this issue, we introduce a knowledge-based(More)
We present a novel free-energy calculation method that constructively integrates two distinct classes of nonequilibrium sampling techniques, namely, driven (e.g., steered molecular dynamics) and adaptive-bias (e.g., metadynamics) methods. By employing nonequilibrium work relations, we design a biasing protocol with an explicitly time- and history-dependent(More)
Membrane transporters actively translocate their substrate by undergoing large-scale structural transitions between inward- (IF) and outward-facing (OF) states ('alternating-access' mechanism). Despite extensive structural studies, atomic-level mechanistic details of such structural transitions, and as importantly, their coupling to chemical events(More)
  • Esmaeil Malek Akhlagh, Mahmoud Moradi, Mehran Mehdizade, Nahid Dorostkar Ahmadi
  • 2012
Innovation strategy is the basis of success in innovation and performance improvement. This paper represents a model related to the most important innovation strategies which have a significant impact on performance of industries. Then, it examines the relationships between innovation strategies and diversity and development of the performance. So, the(More)
  • Stephane Brunel, Marc Zolghadri, Mahmoud Moradi, Adresse Professionnelle
  • 2010
Resume: In this paper we will find an original approach about knowledge in design process. It's not really a new field. It appears that the merge between design and knowledge management propose some very interesting questions. For example, in this paper we ask some questions about the role of collecting, reorganisation and using of knowledge from design(More)