Maher Abd El-Aziz El-Hashash

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A number of novel heterocyclic chalcone derivatives can be synthesized by thermal and microwave tools. Treatment of 4-(4-Acetylamino- and/or 4-bromo-phenyl)-4-oxobut-2-enoic acids with hydrogen peroxide in alkaline medium were afforded oxirane derivatives 2. Reaction of the epoxide 2 with 2-amino-5-aryl-1,3,4-thiadiazole derivatives yielded chalcone of(More)
Maher A El-Hashash1, Dalal B Guirguis1*, Nayera AM Abd El-Wahed2 and Mohamed A Kadhim3 1Chemistry Department, Faculty of Science, Ain Shams University, Abassia 11566, Cairo, Egypt 2Department of Chemistry of Natural and Microbial Products, Division of Pharmaceutical Industries, National Research Center, El Behos street, Dokki, Egypt 3Chemistry Department,(More)
In trying to develop new anticancer agents, a series of 1H-pyrazolo[3,4-b]pyridine derivatives was designed and synthesized. Fifteen compounds were evaluated in vitro for their anti-proliferative activity against HePG-2, MCF-7, HCT-116, and PC-3 cell lines. Additionally, DNA binding affinity of the synthesized derivatives was investigated as a potential(More)
2- Ethoxy-4(3H) quinazolinone 1 was synthesized and allowed to react with various halides, namely: alkyl, benzyl, allyl, acyl, haloacetyl, crotonyl, benzoyl, 2-furoyl and 1-naphthalenesulphonyl halides affording quinazoline and quinazolinone derivatives. The reactions of compound 1 with phosphorus oxychloride, phosphorus pentasulfide, ethyl chloroformate,(More)
New diaryl-3-cyano-1H-pyridinone derivatives 2a–c were synthesized. They were reacted with phosphorous oxychloride to give the chloro derivatives 3b,c. On the other hand, the pyridine derivative 2a was used for the preparation of thienopyridine derivative 4a. Further 2b,c were glycosidated with 2,3,4,6-tetra-O-acetyl-α-glucopyranosyl bromide (αABG) to(More)
The behavior of 2-ethoxy-(4H)-3,1-benzoxazin-4-one (1) towards nitrogen nucleophiles, e.g. ethanolamine, aromatic amines (namely: p-toluidine, p-anisidine, p-hydroxyaniline, o-hydroxyaniline, o-bromoaniline, o-phenylenediamine, p-phenylenediamine, o-tolidinediamine) p-aminobenzoic acid, glucosamine hydrochloride, 2-aminonicotinic acid, 1-naphthalenesulfonic(More)
A series of pyrazolyl-triazolo[1,5-a]pyrimidines, pyrazolyl-tetrazolo[1,5-a]pyrimidines, pyrazolyl-benzo[4,5]imidazo[1,2-a]pyrimidines and bis-azolopyrimidines were prepared by reaction of pyrazolyl-chalcones or its bis-pyrazolyl-chalcones with the appropriate heterocyclic amines as aminotriazole, aminotetrazole, 2-aminobenzimidazole and(More)
A series of novel 1,3,4-thiadiazol-4,5-dihydropyridazin-3(2H)-ones with expected antimicrobial activity have been synthesized. The synthetic protocol of the target compounds was accomplished by condensing β-aroylacrylic acid 1 with 2,5-diamino-1,3,4-thiadiazole 2 to afford the aza-Michael adduct 3. Subsequently, the obtained adduct 3 was cyclized to(More)
The reaction of progesterone 1 with different aromatic aldehydes refluxed in absolute ethanol in the presence of sodium hydroxide afforded new progesterone chalcone hybrids (2a-e). Chalcone progesterone 2b reacted with (cyclohexyl amine, o-anisidine and p-toluidine) in boiling absolute ethanol to yield the corresponding adducts (3, 4 and 5). Treatment of 2b(More)
The reactions of 2-ethoxy-4-hydrazinoquinazoline 2 with diethyl oxalate and ethyl chloroacetate gave 6-ethoxy-2H-[1,2,4]triazino[4,3-c]quinazoline-3,4-dione 3 and 6-ethoxy-2,3-dihydro-4H-[1,2,4]triazino[4,3-c]quinazolin-4-one 4 respectively. A series of 5-ethoxy-2-X-[1,2,4]triazolo[1, 5-c]quinazolines 5a-d was also produced by reacting 2 with the acid(More)