Maher A. El-Hashash

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A number of novel heterocyclic chalcone derivatives can be synthesized by thermal and microwave tools. Treatment of 4-(4-Acetylamino- and/or 4-bromo-phenyl)-4-oxobut-2-enoic acids with hydrogen peroxide in alkaline medium were afforded oxirane derivatives 2. Reaction of the epoxide 2 with 2-amino-5-aryl-1,3,4-thiadiazole derivatives yielded chalcone of(More)
A series of novel 1,3,4-thiadiazol-4,5-dihydropyridazin-3(2H)-ones with expected antimicrobial activity have been synthesized. The synthetic protocol of the target compounds was accomplished by condensing β-aroylacrylic acid 1 with 2,5-diamino-1,3,4-thiadiazole 2 to afford the aza-Michael adduct 3. Subsequently, the obtained adduct 3 was cyclized to(More)
The behavior of 2-ethoxy-(4H)-3,1-benzoxazin-4-one (1) towards nitrogen nucleo-derivatives of 2-aminothiodiazole has been investigated. The behavior of the benzoxazinone towards a selected sulfur nucleophile, L-cysteine, has also been discussed. Formation of an amidine salt as a reaction intermediate has been assumed. The effect of solvent in some reactions(More)
2- Ethoxy-4(3H) quinazolinone 1 was synthesized and allowed to react with various halides, namely: alkyl, benzyl, allyl, acyl, haloacetyl, crotonyl, benzoyl, 2-furoyl and 1-naphthalenesulphonyl halides affording quinazoline and quinazolinone derivatives. The reactions of compound 1 with phosphorus oxychloride, phosphorus pentasulfide, ethyl chloroformate,(More)
The reaction of progesterone 1 with different aromatic aldehydes refluxed in absolute ethanol in the presence of sodium hydroxide afforded new progesterone chalcone hybrids (2a-e). Chalcone progesterone 2b reacted with (cyclohexyl amine, o-anisidine and p-toluidine) in boiling absolute ethanol to yield the corresponding adducts (3, 4 and 5). Treatment of 2b(More)
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