Mahendran Chetty

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The importance of intratumour genetic and functional heterogeneity is increasingly recognised as a driver of cancer progression and survival outcome. Understanding how tumour clonal heterogeneity impacts upon therapeutic outcome, however, is still an area of unmet clinical and scientific need. TRACERx (TRAcking non-small cell lung Cancer Evolution through(More)
An exacerbation of chronic obstructive pulmonary disease (COPD) is the most common respiratory condition necessitating admission to hospital. Many of these are relatively mild in nature and as a consequence, there is increasing interest in immediate and early discharge of patients with nonsevere exacerbations. Following initial assessment, "hospital at(More)
A 67 years old female with previous breast cancer and a 40-pack year smoking history presented with recurrent lower respiratory tract infections on a background of chronic obstructive pulmonary disease. Despite a normal chest X-ray, the history of recurrent infections led to a high resolution computed tomography scan to exclude structural lung disease. This(More)
A South African girl with CANDLE Syndrome is reported with emphasis on the orodental features and dental management. Clinical manifestations included short stature, wasting of the soft tissue of the arms and legs, erythematous skin eruptions and a prominent abdomen due to hepatosplenomegaly. Generalized microdontia, confirmed by tooth measurement and(More)
All investigations were undertaken with full ethical approval in accordance with the Declaration of Helsinki as updated in the version promulgated in June 2013 and the Singapore Statement on Research Integrity. Ethics approval was received from the University of Cape Town (no. 203/2013) and valid until May 2015 2 AUTHORS' CONTRIBUTIONS 1. TR made(More)
prompt response in all sites of disease. We have described two patients in whom the diagnosis of metastatic urological cancer was conveniently , efficiently and quickly made by using EBUS-TBNA. To our knowledge, there is only one published report of metastatic renal cancer being diagnosed using this technique 1 and no reports of metastatic prostate cancer(More)
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