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  • Mahdis Monajemi, Claire F. Woodworth, Jessica Benkaroun, Michael D Grant, Mani Larijani
  • Medicine, Biology
  • Retrovirology
  • 2012 (First Publication: 30 April 2012)
  • The enzyme APOBEC3G (A3G) mutates the human immunodeficiency virus (HIV) genome by converting deoxycytidine (dC) to deoxyuridine (dU) on minus strand viral DNA during reverse transcription. A3GContinue Reading
  • Mahdis Monajemi, Claire F. Woodworth, Katrin Zipperlen, Maureen Gallant, Michael D Grant, Mani Larijani
  • Biology, Medicine
  • PloS one
  • 2014 (First Publication: 10 April 2014)
  • Due to constitutive expression in cells targeted by human immunodeficiency virus (HIV), and immediate mode of viral restriction upon HIV entry into the host cell, APOBEC3G (A3G) and APOBEC3F (A3F)Continue Reading
  • Krista D Squires, Mahdis Monajemi, Claire F. Woodworth, Michael D Grant, Mani Larijani
  • Medicine
  • Journal of acquired immune deficiency syndromes
  • 2015 (First Publication: 1 October 2015)
  • We previously showed that APOBEC-mediated mutations in HIV CD8 T-cell epitopes generally reduce recognition by CD8 T cells. Here, we examined this effect in the context of histocompatibility-linkedContinue Reading
  • Eyler N Ngoh, Hayley K Brugger, +7 authors Laura M. Sly
  • Medicine, Biology
  • Genes and Immunity
  • 2015 (First Publication: 30 July 2015)
  • Crohn’s disease (CD) is a polygenic immune-mediated disease characterized by gastrointestinal inflammation. Mice deficient in the hematopoietic-restricted SH2 domain-containing inositolpolyphosphateContinue Reading