Mahasen Mohamed Meshali

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The objective of this study was to evaluate the effect of formulation composition and continuous ultrasound at 1.5 W/Cm² intensity on the permeation of ibuprofen across polymeric and biological barriers. In vitro studies were performed using cellulose membrane and rabbit skin, whereas in vivo studies were performed on rabbits. Overall, higher transport data(More)
The objective of this study was to evaluate the effect of intensity, mode, and duration of ultrasound application on the transport of three nonsteroidal anti-inflammatory drugs (NSAIDs) across cellulose membrane and rabbit-skin. Ibuprofen, piroxicam and diclofenac sodium were used as the model drugs. Studies were performed in vitro using a modified Franz(More)
The histone deacetylase inhibitor suberoylanilide hydroxamic acid, known as vorinostat, is a promising anticancer drug with a unique mode of action; however, it is plagued by low water solubility, low permeability, and suboptimal pharmacokinetics. In this study, poly(ethylene glycol)-b-poly(DL-lactic acid) (PEG-b-PLA) micelles of vorinostat were developed.(More)
Salbutamol sulfate beads were prepared using anionic and cationic polysaccharides, Gelrite and chitosan, respectively. Alginate beads were also prepared for comparison. The mean diameter, porosity, and drug content of the beads were determined. The beads were examined by scanning electron microscopy (SEM), DSC, and x-ray diffraction. The drug release from(More)
The adsorption of the urinary tract analgesic, phenazopyridine hydrochloride (PN . HCl), on some silicates as pharmaceutical adjuvants was studied. From Langmuir adsorption isotherms the adsorption capacities were determined. The results revealed that the adsorption capacities of veegum and bentonite were comparatively higher than kieselguhr, talc and(More)
Sulfadiazine granules were prepared in a fluidized bed granulator. The granulation conditions such as binder concentration, velocity and temperature of fluidizing air, pressure of compressed air and binder solution flow rate were studied at two levels, low and high. By applying fractional factorial design the effect of these granulation conditions as well(More)
A stable controlled release resinate-complex for the highly bitter taste famotidine (FAM) was developed to allow once-daily administration and improve patient compliance especially in pediatric and geriatric medicine. The drug-resinate complexes were prepared in different drug to resin (Amberlite IRP-69) ratios by weight (1:1, 1:2, 1:3, 1:4, 1:5 and 1:6).(More)
Effects of tromethamine (Tris), polyvinylpyrrolidone (PVP-K25), and low molecular weight chitosan (LM-CH) on dissolution and therapeutic efficacy of glimepiride (Gmp) were investigated using physical mixtures (PMs), coground mixtures, coprecipitates (Coppts) or kneaded mixtures (KMs), and compared with drug alone. Fourier transform infrared spectroscopy,(More)
The dissolution rates of trimethoprim (T), and sulphamethoxazole (S), from different brands of tablets and suspensions were studied at pH = 1.1 and 7.2. The bioavailabilities of both drugs in humans were studied by the urine excretion method. The dissolution rates were dependent on the pH of the dissolution medium, the solubilities of the drugs at the pH(More)