Mahabeer Prasad Dobhal

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BACKGROUND Oxidative stress, produced under diabetic conditions, may cause tissue damage. Although several drugs are currently available for the treatment of diabetes, their continued use may cause unwanted side effects. The aim of the present study was to evaluate the antioxidant potential of β-sitosterol (BS), a phytosterol from Solanum surattense, using(More)
BACKGROUND & OBJECTIVES The severe toxicity, exorbitant cost and emerging resistance of Leishmania species against most of the currently used drugs underscores the urgent need for the alternative drugs. The present study evaluates in vitro anti-leishmanial activity of Plumeria bicolor and its isolated compounds. METHODS The in vitro anti-parasitic(More)
The term epilepsy is collectively designated for a group of chronic central nervous system disorders characterized by spontaneous occurrence of seizures generally associated with the loss of consciousness and body movements (convulsions). The disease has its origin from an early age. Anticonvulsant drugs are used to control the convulsions by inhibiting the(More)
BACKGROUND AND OBJECTIVES Because of the developing resistance of Mycobacterium species against currently available anti-mycobacterial drugs, there is an urgent need for new drug development. In this study, we have evaluated the in vitro anti-mycobacterial activity of Plumeria bicolor extract and its phytoconstituents - plumericin and isoplumericin against(More)
Oral administration of saponins isolated from Albizia lebbeck bark at the dose level of 50 mg/kg/b.w. per day for 60 days to male rats brought about a significant decrease in the weights of testes, epididymides, seminal vesicle and ventral prostate. The production of round spermatid was reduced by 73.04% in Albizia lebbeck treated rats. The population of(More)
Oral administration of root extract of Barleria prionitis L. to male rats (100 mg/rat per day) for the period of 60 days did not cause body weight loss. The root extract brought about an interference with spermatogenesis. The round spermatids were decreased by 73.6% (P< or =0.001). No significant change was found in the population of secondary(More)
Oral feeding of male rats with the ethanolic leaf extract of Colebrookia oppositifolia at dose levels of 100 and 200 mg/kg for 8-10 weeks did not cause body weight loss, while the weights of testes and epididymides were significantly decreased. Seminal vesicles and ventral prostate showed a significant reduction at the higher dose only. Treated animals(More)
Recently, a review has already been made on the synthetic contraceptive agents whereas this review embraces the natural contraceptives upto year 2001 with 355 references. It also includes the isolation of their active principles, methods of analysis of active ingredients through TLC, HPLC, their side effects and pharmacological action.
AIM To evaluate the antifertility effect of Alstonia scholaris bark extract in male rats. METHODS In male Wistar rats Alstonia scholaris bark extract was given by oral route at a dose of 200 mg/day for 60 days. The fertility and testicular function were assessed by mating tests, sperm motility, sperm concentration, biochemical indices and testicular cell(More)
This study was conducted to evaluate the antifertility potential of Thevetia peruviana (Apocynaceae) in male albino rats with their phytochemical evaluations. Phytochemical examination showed that plant is rich in active constituents, i.e. α-amyrin acetate, lupeol acetate, α-amyrin, β-amyrin, lupeol and thevetigenin. T. peruviana stem bark methanol extract(More)