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Dbf4-Dependent Cdc7 Kinase Links DNA Replication to the Segregation of Homologous Chromosomes in Meiosis I
TLDR
It is shown that in yeast, the Dbf4-dependent Cdc7 kinase (DDK) provides a link between premeiotic S phase, recombination, and monopolar attachment and activation of DDK both initiates DNA replication and commits meiotic cells to reductional chromosome segregation in the first division of meiosis. Expand
A Genome-Scale DNA Repair RNAi Screen Identifies SPG48 as a Novel Gene Associated with Hereditary Spastic Paraplegia
TLDR
A novel gene in a genome-wide, double-strand break DNA repair RNAi screen is identified and shown to be involved in the neurological disease hereditary spastic paraplegia. Expand
A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity.
TLDR
A genome-scale RNAi screen for a global survey of genes affecting ESC identity via alteration of Oct4 expression shows that the Paf1C binds to promoters of key pluripotency genes, where it is required to maintain a transcriptionally active chromatin structure. Expand
Motor-Independent Targeting of CLASPs to Kinetochores by CENP-E Promotes Microtubule Turnover and Poleward Flux
TLDR
It is concluded that CENP-E integrates two critical functions that are important for accurate chromosome movement and spindle architecture: one relying directly on its motor activity, and the other involving the targeting of key microtubule regulators to kinetochores. Expand
Comparative profiling identifies C13orf3 as a component of the Ska complex required for mammalian cell division
TLDR
It is shown that the analysis of protein localisation is useful to refine a phenotypic profile and identified C13orf3 (Ska3) as a new component of the Ska complex and show a direct interaction with a regulatory subunit of the protein phosphatase PP2A. Expand
A genomic toolkit to investigate kinesin and myosin motor function in cells
TLDR
This work generated a library of 243 amino- and carboxy-terminally tagged mouse and human bacterial artificial chromosome transgenes to establish 227 stably transfected HeLa cell lines, 15 mouse embryonic stem cell lines and 1 transgenic mouse line, providing a set of validated resources and candidate molecular pathways to investigate motor protein function across cell lineages. Expand
A systematic RNAi synthetic interaction screen reveals a link between p53 and snoRNP assembly
TLDR
The molecular dependency network of TP53 is explored through an RNAi-mediated synthetic interaction screen employing two HCT116 isogenic cell lines and a genome-scale endoribonuclease-prepared short interfering RNA library to unmasking the complex connections of p53 to cellular physiology and growth control. Expand
Changes in the 2-DE protein profile during zygotic embryogenesis in the Brazilian Pine (Araucaria angustifolia).
TLDR
Estimates on the improvement and control of somatic embryogenesis through medium manipulation and protein markers screening using data generated provide new insights into the process of embryogenesis in this recalcitrant species. Expand
Protein identification pipeline for the homology-driven proteomics.
TLDR
This paper addresses practical aspects of automated homology-driven protein identifications by LC-MS/MS on a hybrid LTQ Orbitrap mass spectrometer. Expand
Differential proteomic serum pattern of low molecular weight proteins expressed by adenocarcinoma lung cancer patients.
TLDR
2D-gel electrophoresis and mass spectrometry proteomic techniques are shown to be useful for the identification of up- and down-regulated proteins in serum from adenocarcinoma lung cancer patients. Expand
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