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The VHL tumour suppressor gene codes for von-Hippel Lindau (VHL) protein which acts by association with Elongin C and Hypoxia Inducing Factor-1 alpha (HIF). Two functional sub-domains in the protein model of VHL contain binding sites for these proteins. Alpha domain of VHL protein contains the binding site for Elongin C (tumorigenic cluster A) whereas; the(More)
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