Magdalena Wójtowicz

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We investigated the p53 status and the ability of exogenous wildtype (wt) p53 to affect chemosensitivity in three anaplastic thyroid carcinoma cell lines (BHT-101, SW-1736, and KAT-4). All three cell lines had nonfunctional p53. Treatment with mitomycin C or adriamycin did not result in accumulation of p53 or induction of p21WAF1/CIP1 or Mdm-2 and did not(More)
Sex hormone-binding globulin (SHBG) is a serum (serous) glycoprotein binding estrogens and androgens with high affinity. Hepatic synthesis of SHBG and serous protein concentration are related to the following factors: age, sex steroids and thyroid hormones concentrations, obesity. Along with aging process, an increase of SHBG concentration is observed in(More)
Melatonin may be a key factor in regulation of seasonal variation in gonadal activity. The circadian disturbances related to reproduction are probably subsequent to the seasonal change. Moreover, melatonin might also be considered essential to both spermatogenesis and folliculogenesis. Exposure to bright light, suppressing the concentration of melatonin in(More)