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Degradation of Human Antimicrobial Peptide LL-37 by Staphylococcus aureus-Derived Proteinases
Data suggest that aureolysin production by S. aureus contributes to the resistance of this pathogen to the innate immune system of humans mediated by LL-37. Expand
Genomic Characterization of Methanomicrobiales Reveals Three Classes of Methanogens
The results indicate that Methanomicrobiales, rather than being similar to Class I methanogens or Methanosarcinales, share some features of both and have some unique properties. Expand
Biochemical and genetic characterization of an early step in a novel pathway for the biosynthesis of aromatic amino acids and p‐aminobenzoic acid in the archaeon Methanococcus maripaludis
The initial reactions of a new pathway for the biosynthesis of PABA in methanococci are identified and the expected enrichments for phenylalanine and arylamine derived from PABA were observed. Expand
Properties of the reversible nonoxidative vanillate/4-hydroxybenzoate decarboxylase from Bacillus subtilis.
Bacillus subtilis (ATCC 6051) reversibly decarboxylates vanillate and 4-hydroxybenzoate under both aerobic and anoxic conditions. Thus, we have identified on the basis of gene sequence homology withExpand
Cysteine Is Not the Sulfur Source for Iron-Sulfur Cluster and Methionine Biosynthesis in the Methanogenic Archaeon Methanococcus maripaludis*
This investigation challenges the concept that cysteine is always the sulfur source for Fe-sulfur cluster biosynthesis in vivo and suggests that Fe-S clusters are derived from sulfide in those organisms, which live in sulfide-rich habitats. Expand
Methanococcus aeolicus sp. nov., a mesophilic, methanogenic archaeon from shallow and deep marine sediments.
Three strains of CO(2)-reducing methanogens were isolated from marine sediments. Strain PL-15/H(P) was isolated from marine sediments of the Lipari Islands, near Sicily and the other two strains,Expand
Complete genome sequence of Methanoculleus marisnigri Romesser et al. 1981 type strain JR1
The complete genome sequence of M. marisnigri type strain JR1 and its annotation is reported here as part of a Joint Genome Institute 2006 Community Sequencing Program to sequence genomes of diverse Archaea. Expand
Complete genome sequence of Methanocorpusculum labreanum type strain Z
The complete genome sequence of M. labreanum type strain Z is reported here as part of a 2006 Joint Genome Institute Community Sequencing Program project to sequence genomes of diverse Archaea. Expand
Characterization of the specificity of arginine-specific gingipains from Porphyromonas gingivalis reveals active site differences between different forms of the enzymes.
Porphyromonas gingivalis is a pathogen associated with periodontal disease, and arginine-specific proteases (gingipains-R) from the bacterium are important virulence factors. The specificity of twoExpand
Synthesis of amide and sulfonamide substituted N-aryl 6-aminoquinoxalines as PFKFB3 inhibitors with improved physicochemical properties.
Series of amides and sulfonamides derivatives based on a N-aryl 6-aminoquinoxaline scaffold were synthesized and tested for their inhibition of PFKFB3 in vitro in a biochemical assay as well as in HCT116 cells, and the carboxamide series displayed satisfactory kinetic solubility and metabolic stability. Expand