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Phage Display Derived IgNAR V Region Binding Domains for Therapeutic Development.
Phage display technology has revolutionized the science of drug discovery by transforming the generation and manipulation of ligands, such as antibody fragments, enzymes, and peptides. The basis ofExpand
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Next-generation flexible formats of VNAR domains expand the drug platform's utility and developability.
TLDR
Smaller, less complex binders, with increased domain valency, multi-specific/paratopic targeting, tuneable serum half-life and low inherent immunogenicity are a few of the characteristics being explored by the next generation of biologic molecules. Expand
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13CO2 breath tests in non-invasive hepatological diagnosis
In liver diagnostics, a simple, non-invasive test with high sensitivity and specificity is permanently being sought in order to assess the degree of liver damage. In addition to liver biopsy,Expand
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Pragmatically on the sense of taste – a short treatise based on culinary art
The sense of taste is essential for proper functioning of the organism. The authors describe, in an accessible way, the complex mechanisms of taste perception. The structure of particular tasteExpand
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The effect of drugs and stimulants on gastric myoelectrical activity
Electrogastrography (EGG) is a non-invasive diagnostic method useful for the registration and analysis of gastric myoelectrical activity. Abnormalities within an electrogastrogram were found toExpand
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Isolation of highly selective IgNAR variable single-domains against a human therapeutic Fc scaffold and their application as tailor-made bioprocessing reagents.
The adaptive immune system of cartilaginous fish (Elasmobranchii), comprising of classical hetero-tetrameric antibodies, is enhanced through the presence of a naturally occurring homodimericExpand
In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties.
VNAR domains are the binding regions of new antigen receptor proteins (IgNAR) which are unique to sharks, skates, and rays (Elasmobranchii). Individual VNAR domains can bind antigens independentlyExpand
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