Magdalena Briones-Velasco

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The effects of a mild hypothyroidism condition on benzodiazepine (BDZ) and mu opioid receptor levels was investigated. Female Wistar rats were randomly divided into two groups: 1) hypothyroid rats (n=7), which received methimazole (60 mg/kg per day) in drinking water for four weeks, and 2) euthyroid rats (n=8), which drank only tap water. Animals were(More)
A putative role of the brain-derived neurotrophic factor (BDNF) in epilepsy has emerged from in vitro and animal models, but few studies have analyzed human samples. We assessed the BDNF expression of transcripts with exons I (BDNFI), II (BDNFII), IV (BDNFIV) and VI (BDNFVI) and methylation levels of promoters 4 and 6 in the hippocampi of patients with(More)
The etiology of attention deficit hyperactivity disorder (ADHD) is complex and multifactorial, with an important genetics load. Pharmacological, animal, and brain image studies provide significant evidence that monoamine genes are relevant (Gizer et al., 2009). We aimed to explore the possible association between Val158Met COMT, VNTR 3 0 UTR SLC6A, and LPR(More)
BACKGROUND The interplay among lifetime adversities and the genetic background has been previously examined on a variety of measures of depression; however, only few studies have focused on major depression disorder (MDD) in adolescence. METHODS Using clinical data and DNA samples from mouthwash gathered from an epidemiological study on the prevalence of(More)
SUMMARY Family, twin and adoption studies suggest that genetics plays an important role in the etiology of many psychiatric disorders. It has been proposed that the dopaminergic brain system could be affected in schizophrenia, substance abuse and attention deficit hyperactivity disorder. The most studied genes are two VNTR polymorphic systems; one located(More)
A body of evidence supports a relevant role of brain-derived neurotrophic factor (BDNF) in temporal lobe epilepsy (TLE). Magnetic resonance data reveal that the cerebral atrophy extends to regions that are functionally and anatomically connected with the hippocampus, especially the temporal cortex. We previously reported an increased expression of BDNF(More)
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