Magda M. Assem

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Background: AML blasts of different FAB subsets express specific chemokines and chemokine receptors depending on their degree of maturation which might account for some aspects in their pattern of extramedullary invasion (EMI) and accumulation of leukemic cells. Objectives: We aimed to define the pattern of chemokine MCP-1 and chemokine receptors CXCR4 and(More)
Acute myeloid leukemia (AML) is the most common type of leukemia in adults with the lowest survival rate of all the leukemias. It is a heterogeneous disease in which a variety of cytogenetic and molecular alterations have been identified. Some galectins were previously reported to have important roles in cancer-like neoplastic transformation, tumor cell(More)
Molecular characterization of acute myeloid leukemia (AML) allows prognostic stratification and assessment of the chances of durable treatment response. The presence of FLT3 internal tandem duplication (ITD) mutation as well as the allelic ratio (ITD-AR) and JAK2 V617F mutation may be associated with clinical outcome in patients with AML. FLT3-ITD and JAK2(More)
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