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CONTEXT MicroRNA (miRNA) are an important class of regulators of gene expression. Altered miRNA expression has been constantly found in human neoplasias and plays an important role in the process of carcinogenesis. OBJECTIVE The aim of this study was to identify specific miRNA whose expression is altered in GH-secreting pituitary adenomas. DESIGN Using(More)
BACKGROUND & AIMS Ribavirin monotherapy is the preferred treatment for chronic hepatitis E, although occasional treatment failure occurs. We present a patient with chronic hepatitis E experiencing ribavirin treatment failure with a completely resistant phenotype. We aimed to identify viral mutations associated with treatment failure and explore the(More)
(With the technical assistance of Adelina ()/eda, Alvaro Carstens and Iris Dugarte) H EAVY HOOKWORM INFECTION is sooner or later associated with iron deficiency anemia mainly due to continuous intestinal blood loss. A mean daily intestinal blood loss of 0.031 ± 0.017 ml. per worm and 2.14 ± 1.0 ml. of hlocd per 1,000 ova per gram of feces was found by means(More)
Integrative genomics approaches associating DNA structure and transcriptomic analysis should allow the identification of cascades of events relating to tumor aggressiveness. While different genome alterations have been identified in pituitary tumors, none have ever been correlated with the aggressiveness. This study focused on one subtype of pituitary(More)