Magali E. Droniou-Bonzom

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Candid#1 (Cd1) is an attenuated vaccine strain of Junin virus, the causative agent of Argentine hemorrhagic fever. Although several substitutions are present in Cd1, their importance for attenuation has not been established. We functionally characterized the substitutions present in the Cd1 glycoprotein (GP) and identified F427I in the transmembrane domain(More)
Clade B of the New World arenaviruses contains both pathogenic and nonpathogenic members, whose surface glycoproteins (GPs) are characterized by different abilities to use the human transferrin receptor type 1 (hTfR1) protein as a receptor. Using closely related pairs of pathogenic and nonpathogenic viruses, we investigated the determinants of the GP1(More)
The gibbon ape leukemia virus (GaLV) Env protein mediates entry into a wide range of human cells and is frequently used to pseudotype retroviral vectors. However, an incompatibility exists between GaLV Env and lentiviral vectors that results in decreased steady-state levels of the mature GaLV Env in cells and prevents its incorporation into lentiviral(More)
1 Substitutions in the glycoprotein (GP) of the Candid#1 vaccine strain of Junin virus 2 increase dependence on human transferrin receptor 1 for entry and destabilize the 3 metastable conformation of GP. 4 5 6 Magali E. Droniou-Bonzom, Therese Reignier, Jill E. Oldenburg, Alex U. Cox, Colin M. 7 Exline, Jessica Y. Rathbun, and Paula M. Cannon.* 8 9(More)
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